Examples of 'variable region' in a sentence
Meaning of "variable region"
variable region: In biology and immunology, the variable region is the part of an antibody or antigen receptor that is highly diverse and specific to recognizing and binding to a particular antigen. This region undergoes genetic rearrangement and mutation to generate a wide range of unique antigen-binding sites, allowing the immune system to respond to various pathogens and foreign substances
How to use "variable region" in a sentence
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variable region
For example the whole variable region.
The antibody variable region can be attached to a cytokine.
At least partially purifying the variable region.
Immunoglobulin variable region cassette exchange.
Variable region framework residues have little or no direct contribution.
The linker may be a variable region linking sequence.
The variable region differs from one antibody to another.
Construction of cDNA encoding variable region of humanized antibody.
Mouse variable region and human constant region.
Analysis of amino acid sequence of variable region of antibody.
The human variable region to be used to elicit antibodies.
The idiotope is found in the variable region of the antibody.
The variable region is in capital letters and is not underlined.
Methods of making a nucleic acid encoding a human variable region.
Cloning of variable region cDNAs.
See also
Direct cDNA cloning of the rearranged immunoglobulin variable region.
The antibody variable region of the invention are attached to a cytokine.
In particular embodiments the linker is a variable region linking sequence.
The antibody variable region of the invention can be attached to a cytokine.
This plasmid provides the remaining variable region sequence.
Hyper variable region.
The antibody should comprise at least a variable region domain.
This variable region is initially expressed linked to a cleavable signal peptide.
Each of the three CDRs in each variable region is underlined.
The variable region binds to and interacts with a target antigen.
The two hydrophilic peaks in the variable region are overlined.
For each variable region cDNA two primers are preferably designed.
Modification of amino acid sequence of variable region of humanized antibody.
The variable region is dependent on the variable knowledge and practice of rotation.
In turn the chains comprise a variable region and a constant region.
Each heavy chain has a constant region and a variable region.
The variable region of those antibodies can be identified using standard techniques.
Immunoglobulin variable region.
Antibodies are further divided into a constant region and a variable region.
The immunoglobulin chains comprise a variable region and a constant region.
Changes in the variable region may be made to alter antigen binding characteristics.
A portion of an immunoglobulin can include a variable region or a constant region or both.
The variable region is typically present in the genome of the cell strains.
Each light chain is comprised of a constant region and a variable region.
Therefore the correct variable region sequences have been identified and cloned.
Region protein or at or near ends of the different variable region proteins.
In particular cognate pairs of variable region encoding sequences are linked by this process.
In naturally occurring TcRs there are four CDRs in each variable region.
A steric structural model of variable region of this clone was prepared and analyzed.
The variable region domain will in general be capable of selectively binding to an antigen.
Each of the chains is comprised of a variable region and a constant region.
It is the variable region that provides the specificity for a particular antigen.
Each of the polypeptide consists of a variable region and constant region.
Only part of the variable region participates directly in the binding of antigen.
Exemplary ligands may be receptor antagonists or a variable region of an immunoglobulin molecule.
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