Examples of 'variable regions' in a sentence
Meaning of "variable regions"
In the context of biology or genetics, it refers to the segments of DNA or RNA molecules that have variable sequences. These regions often determine the diversity in functional properties or characteristics, especially within proteins or antibodies
How to use "variable regions" in a sentence
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variable regions
The specificity of the variable regions of antibodies.
The variable regions of the light chains.
The identified sequences of variable regions are as follows.
The variable regions were initially shaped randomly.
Modeling the structure of the variable regions.
Minor variable regions are not shown.
The boxed regions show variable regions.
Fv variable regions of an antibody with specific antigen binding.
These are referred to as variable regions or epitopes.
The variable regions are in upper case.
It is composed of human constant and murine variable regions.
Heavy and light variable regions are marked in bold.
Variable regions are regions not underlined.
Oligonucleotides were designed in the conserved and variable regions.
Such variable regions are typically more amenable to change.
See also
A further refinement involves humanization of the variable regions.
Sequencing of variable regions of selected antibodies.
Variable domains are also referred herein as variable regions.
Selection of the human variable regions is considered to be of critical importance.
Design of the reshaped variable regions.
Variable regions will be sequenced.
It is comprised of human constant and murine variable regions.
The humanized variable regions were inserted into expression vectors.
Preferably the first and second variable regions are deleted.
Preferably the variable regions of the antibodies are cognate pairs.
Cloning immunoglobulin variable regions.
Variable regions may be obtained from any suitable source.
It is also possible to connect both variable regions by means of a linker.
The variable regions are primarily responsible for antigen binding.
The correct sequences of the variable regions were confirmed by sequencing.
Such variable regions can be combined with human constant regions.
These sections represent highly variable regions of the spectrum.
Binding of the variable regions is mostly optimized by using ribosome display.
Exemplary peptide chains being compared are heavy or light chain variable regions.
Cloning of the variable regions from hybridoma cell lines.
Infliximab has human constant regions and murine variable regions.
This creates two optically variable regions having a different appearance.
The variable regions therefore determine the specificity of the antibody.
These are analogues of antibody variable regions produced as a single polypeptide chain.
The variable regions of an antibody fragment may also be chimerized or humanized.
Further modifications in the variable regions can also reduce immunogenicity.
Restriction digest and ligation reactions to clone the variable regions.
Mouse variable regions have been identified for many different antigens.
Variability is not usually evenly distributed throughout antibody variable regions.
The remaining parts of the variable regions are referred to as framework regions.
Light and heavy chains consist of constant and variable regions.
Display libraries of antibody variable regions may be constructed by a variety of methods.
The remaining seven changes took place in relatively variable regions.
Single chain variable regions may be produced either recombinantly or synthetically.
The sequence evolution at each of the variable regions is mostly divergent.
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