Examples of 'affinity maturation' in a sentence
Meaning of "affinity maturation"
affinity maturation - a process in immunology where B cells produce antibodies with increased affinity for a specific antigen
How to use "affinity maturation" in a sentence
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affinity maturation
Methods of affinity maturation are known in the art.
This process is called antibody affinity maturation.
Affinity maturation is achieved through two processes.
Humanization can also include affinity maturation.
Affinity maturation and clonal families.
Activation leads to clonal expansion and affinity maturation.
Affinity maturation experiments were performed as follows.
Optimization of antibodies derived from first affinity maturation.
Affinity maturation is sometimes carried out using random mutagenesis.
Gamma constant regions assist in affinity maturation of antibodies.
Polypeptide affinity maturation is a particularly preferred embodiment of the invention.
Further sequence refinement can be accomplished by affinity maturation.
Biopanning of the affinity maturation library was performed with biotinylated antigen.
Single parent antibodies may be subject to affinity maturation.
By affinity maturation techniques.
See also
Such antibody variants may be prepared by affinity maturation.
The technique of affinity maturation may be used to improve binding affinity.
The scaffolds of the present disclosure may be subjected to affinity maturation.
B cells may also undergo affinity maturation outside of germinal centers.
This data was used to select four antibodies for further affinity maturation.
This demonstrates antigen driven affinity maturation of the human heavy chain sequences.
The new mutants were discovered in the course of in vitro affinity maturation studies.
Affinity maturation is the process by which antibodies with increased affinity for antigen are produced.
The methodology was successfully used for affinity maturation of small molecule ligands.
The process of generating antibodies with increased binding affinities is called affinity maturation.
This typical pattern of isotype signifies affinity maturation in the immune response.
Tree of affinity maturation pathways from lead binder to expressed extracellular domain of target receptor.
The affinity of an antibody can also be increased by known affinity maturation techniques.
These studies indicate guidelines for affinity maturation of binding interfaces using monovalent phage display.
Antigen binding affinities can also be improved by in vitro affinity maturation refs.
All of these methods of affinity maturation are discussed by Vaughan et al.
In the course of these antibody responses IgG may undergo substantial affinity maturation.
Subsequent affinity maturation mutagenesis in the other CDR positions then optimizes those identified binding molecules.
One method of mutating antibodies involves affinity maturation using phage display.
He demonstrated the importance of somatic hypermutation of immunoglobulin V genes in antibody affinity maturation.
After B cell activation a process of affinity maturation through somatic hypermutation occurs.
Screening methods may involve one or more in vitro or in vivo affinity maturation steps.
Humanization and affinity maturation was conducted in several steps, as follows,.
Thus resulting in less isotype switching and reduced affinity maturation in mAbs produced.
Figure 4 shows affinity maturation of human plasma kallikrein inhibitors.
A convenient way for generating such substitutional variants is affinity maturation using phage display.
Affinity maturation was performed using 4 different phage display libraries.
This will result in the obtention of antibodies which have already undergone affinity maturation.
In total, nine rounds of affinity maturation were performed.
All hybridomas derived from glycoconjugate immunized mice showed class switching and affinity maturation.
In one aspect, no additional affinity maturation is required.
However, affinity maturation strategies require several rounds of mutagenesis and testing.
A convenient way for generating such substitution variants is affinity maturation using phage display.
In some models, affinity maturation of the antibodies can also be monitored.
A convenient way for generating such substitutional variants involves affinity maturation using phage display.
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