Examples of 'bispecific molecules' in a sentence
Meaning of "bispecific molecules"
Bispecific molecules: In biology or pharmacology, bispecific molecules are compounds designed to simultaneously bind to two different molecules or targets, often used in research or therapeutic applications
How to use "bispecific molecules" in a sentence
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bispecific molecules
The purpose is here to obtain at least bispecific molecules.
The bispecific molecules of this invention can be of several configurations.
Only few other companies develop similar bispecific molecules.
Bispecific molecules may comprise at least two single chain molecules.
A further aspect of the invention provides a method for using the bispecific molecules as an immunogen.
Bispecific molecules can come in many different formats and sizes.
Transfectants were screened for expression of soluble chimeric bispecific molecules in an ELISA assay format.
Monovalent bispecific molecules can be efficiently formed using this approach.
Antibodies of the present invention may include antibodies with reduced effector functions and / or bispecific molecules.
One type of bispecific molecules are bispecific antibodies as known in the art.
Antibody derivatives include chimeric molecules, humanized molecules, molecules with reduced effector functions and bispecific molecules.
The bispecific molecules of this invention can also be prepared as recombinant molecules.
Table 1 Binding kinetics of recombinant bispecific molecules.
Such bispecific molecules could be seen as conferring an artificial specificity to immune effector cells.
Preincubation with VEGF-A did not affect internalization of these bispecific molecules.
See also
The bispecific molecules of this invention are specific for interaction with only FcYRI.
Figure 11 is a graph showing results of ELISA assays used to detect chimeric bispecific molecules.
The two bispecific molecules seemed to have similar activities at low antibody concentrations.
The molar stochiometry of binding for the various bispecific molecules are summarized in Table 31.
Compositions containing bispecific molecules which comprise an antibody of the present invention are also provided.
Results The kinetic constants obtained for the various bispecific molecules are summarized in Table 29.
Bispecific Molecules Antibodies described herein may be used for forming bispecific molecules.
Association and dissociation constants were measured for the interaction of the bispecific molecules to VEGF-A.
The bispecific molecules of the present invention can be prepared by conjugating e . g.
Therefore, the binding of the bispecific molecules is not blocked by physiological levels of immunoglobulins.
The bispecific molecules of this invention have a potentially long half-life in vivo.
Methods for preparing bispecific molecules are described for example in U.S. Pat.
All bispecific molecules were simultaneously able to bind both VEGF-A and PDGFRB.
Intermediate-sized bispecific molecules include two different F ( ab ) fragments linked by a peptidyl linker.
The bispecific molecules were further purified by hydrophobic interaction chromatography ( HIC ) on a Phenyl Sepharose column.
Bivalent and bispecific molecules are described in, e.g., Kostelny et al.
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Bispecific antibodies have a higher cytotoxic potential
Methods for producing bispecific antibodies are known
Bispecific antibodies may be human or humanized antibodies
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