Examples of 'chain variable regions' in a sentence
Meaning of "chain variable regions"
chain variable regions: In biology and immunology, chain variable regions refer to the variable parts of immunoglobulin chains, specifically in antibodies, that are responsible for binding to antigens
How to use "chain variable regions" in a sentence
Basic
Advanced
chain variable regions
Regions outside heavy and light chain variable regions are underlined.
Single chain variable regions may be produced either recombinantly or synthetically.
The amplified heavy and light chain variable regions were sequenced.
The present invention also provides antibodies comprising such light chain variable regions.
Light chain and heavy chain variable regions were amplified in separate reactions.
Exemplary peptide chains being compared are heavy or light chain variable regions.
The cloned cDNAs encoding the light chain variable regions were analyzed by sequencing.
The heavy chain variable regions of such antibodies can be derived from any selected antibodies.
The nucleic and amino acid sequences of these light chain variable regions are.
Any of the light chain variable regions may be combined with a suitable constant region.
Single chain antibodies comprise the light and heavy chain variable regions linked by a flexible linker.
Any of the heavy chain variable regions may be combined with a suitable human constant region.
Preferably the ScFv fragment comprises a linker sequence between light chain and heavy chain variable regions.
Immunoglobulin heavy and light chain variable regions were amplified using a semi nested PCR approach.
Typically, the chimaeric antibody comprises both light and heavy chain variable regions.
See also
The heavy and light chain variable regions of rituximab as shown as SEQ ID Nos.
VH amplification primers designed to amplify human heavy chain variable regions are contemplated.
Antibody chain variable regions contain intra-domain disulfide bridges.
CDR region sequences for the heavy and light chain variable regions are noted.
The light and heavy chain variable regions can, optionally, be ligated to corresponding constant regions.
A similar single-chain protein comprising the heavy chain variable regions is also possible.
The heavy and light chain variable regions of 37E1 were refined to make a higher affinity antibody.
VH amplification primers designed to amplify human heavy chain variable regions are shown in Table 6.
Humanized A1 light chain variable regions showed compromised 5T4 binding properties.
Figure 5 shows deduced amino acid sequences of the TNV mAb light chain variable regions.
The heavy chain and light chain variable regions of the antibody e . g.
The candidate antibody sequence is aligned with E3 antibody heavy chain and light chain variable regions.
In various aspects, the light chain variable regions produced by such methods are described.
Example 7 - DNA and amino acid sequence of low and heavy chain variable regions.
A series of humanized heavy and light chain variable regions may be designed by grafting, e . g.
FIG . 12 depicts the DNA and amino acid sequences of exemplary modified heavy chain variable regions.
Sequences of the light and heavy chain variable regions were determined in the following manner,.
Figures 3A-3D show the nucleic acid sequences of the heavy chain variable regions M3 FIG.
In one aspect, the light chain variable regions are human Vk regions.
The kappa chain variable regions were amplified similarly using 29 different 5 ' oligonucleotides and a single 3 ' oligonucleotide.
In combination, the heavy and the light chain variable regions specifically bind the antigen.
The antibody I chain variable regions used were,.
The amino acid sequences of the 2 distinct light chain variable regions are depicted in FIG . 1E.
The sequences of the heavy and light chain variable regions are also depicted in Figure 1A.
The final consensus DNA sequence of the heavy chain variable regions is shown in Figure 3.
Exemplary heavy chain and light chain variable regions sequences are provided in SEQ ID NOS, 7, 8.
Computer modeling of the 15C11 antibody heavy and light chain variable regions is performed as follows.
Nucleotide alignment of cynomolgus kappa light chain variable regions with human, rabbit and mouse sequences.
Specifically, the antibody H chain variable regions used were,.
The similarity of humanized A1 light chain variable regions is shown in Table 10.
The similarity of humanized A1 heavy chain variable regions is shown in Table 10.
As described further below, both A1 heavy chain variable regions retained 5T4 binding properties.
Cloning of light and heavy chain variable regions of anti-CD162 antibodies.
The amino acid sequences of the 22 distinct heavy chain variable regions are depicted in FIGS . 1A -- D.
You'll also be interested in:
Examples of using Variable
Show more
Variable oversight over supply chain activities
Because they have a variable interest rate
This variable reflects quite complex forces
Examples of using Regions
Show more
Regions number of countries with evaluation plans
Some countries or regions have multiple patterns
Regions are hit differently by restructuring of the economy
Examples of using Chain
Show more
I had the chain around its neck
Chain of command is very important in our thing
Direction of the chain movement and teeth
