Examples of 'chain variable region' in a sentence
Meaning of "chain variable region"
chain variable region - in biology, refers to a variable region of a protein or antibody chain that determines specificity in binding to antigens
How to use "chain variable region" in a sentence
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chain variable region
The other sequence was typical of a functional mouse kappa chain variable region.
The light chain variable region can be a humanized or human light chain variable region.
Analyze the heavy chain and light chain variable region sequences.
The light chain variable region is separated from heavy chain variable region by a linker region.
No donor framework residues were retained in the engineered light chain variable region.
The heavy and light chain variable region sequences are shown in the sequence listing.
The antibody contains a mature heavy chain or light chain variable region sequence.
The heavy chain variable region can be a humanized or human variable heavy chain variable region.
This is done independently for both the heavy and light chain variable region sequences.
The light chain variable region is aligned with the variable region of the heavy chain.
The binding domain polypeptide can be a heavy chain variable region or a light chain variable region.
A heavy chain variable region and the constant region of another subclass can be directly linked.
The above first and second polypeptides may additionally comprise an antibody heavy chain variable region.
Chimeric heavy chain variable region and signal nucleotide and amino acid sequences are provided.
The antigen binding domain may comprise a light chain variable region and a heavy chain variable region.
See also
The H chain variable region and the L chain variable region were separately subjected to homology search.
Some humanized antibodies comprise a heavy chain variable region shown in Fig.
A humanized heavy chain variable region and signal sequences are illustrated in Fig.
The antibody is a humanized antibody comprising a heavy chain variable region shown in Fig.
A humanized heavy chain variable region is illustrated in Fig.
In some embodiments, the antibody further comprises an antibody light chain variable region.
Harvesting the immunoglobulin heavy chain variable region and the immunoglobulin light chain variable region.
An antibody or antibody fragment according to claim 1, which comprises a heavy chain variable region having.
CDRs can be located in a heavy chain variable region sequence in the following way.
Nucleotide sequence of the gene for the humanized anti-Tac light chain variable region gene.
The heavy and light chain variable region sequences from the Aximab hybridoma were determined.
In additional embodiments, only the heavy chain variable region is required.
The synthetic heavy chain variable region nucleotide and amino acid sequences are provided in Fig.
Wherein the antibody comprises a light chain variable region comprising,.
A light chain variable region comprising the following CDRs,.
The invention also encompasses the use of single chain variable region fragments ( scFv ).
A heavy chain variable region comprising the following CDRs,.
Instead, they form a dimer by pairing with another single chain variable region fragment.
If a light chain variable region is linked to a constant region, preferably it is a k chain.
In a specific embodiment, the mouse comprises a humanized heavy chain variable region gene segment.
In an embodiment, the heavy chain variable region is preceded by a signal peptide.
Nucleotide sequence of the gene for the humanized anti-Tac heavy chain variable region gene.
The first row shows the heavy chain variable region numbering using the Kabat system.
In one aspect, the non-human animal lacks a functional unrearranged immunoglobulin light chain variable region.
An antibody heavy chain variable region comprising,.
A-3 Amplification and fragmentation of cDNA encoding a mouse heavy chain variable region.
An antibody light chain variable region comprising,.
It was likely that this fragment contained the 7E3 heavy chain variable region gene.
The sequence of the heavy chain variable region of this antibody is, or.
SEQ ID NO, 9 corresponds to the nucleotide sequence of the heavy chain variable region.
In an embodiment, the light chain variable region is preceded by a signal peptide.
A humanized antibody of any of claims 1 to 5 comprising a heavy chain variable region shown in Fig.
A heavy chain variable region comprising the amino acid sequence,.
The antibody of claim 1, wherein said light chain variable region comprises the amino acid sequence.
The heavy chain variable region of several independent clones of pRR62 were sequenced.
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