Examples of 'dna-binding domain' in a sentence
Meaning of "dna-binding domain"
DNA-binding domain: In molecular biology, this phrase refers to a specific region of a protein that binds to DNA. It is crucial for various biological processes, including gene expression and DNA replication
How to use "dna-binding domain" in a sentence
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dna-binding domain
Example of a DNA-binding domain in the context of a protein.
Other embodiments are directed to a protein that comprises a DNA-binding domain.
The DNA-binding domain is composed of two zinc finger motifs.
Each row describes a separate zinc finger DNA-binding domain.
One has a DNA-binding domain of a transcriptional activator fused to a test protein.
Conferred through three zinc fingers in the DNA-binding domain.
In some embodiments, the DNA-binding domain comprises a plurality of repeat sequences.
The extra domains often regulate the activity of the DNA-binding domain.
It contains a highly conserved DNA-binding domain known as the runt domain.
In another embodiment, one or more of the repeat sequences are present in a DNA-binding domain.
The first hybrid comprises a DNA-binding domain fused to the bait protein.
The DNA-binding domain targets the activation domain to the specific genes to be expressed.
In another embodiment, the linker connects a DNA-binding domain to a nuclease domain.
Any DNA-binding domain known in the art can be used as part of a fusión molecule.
The amino acid sequence of the hGR DNA-binding domain is given.
See also
Generally, the DNA-binding domain or gene activating domain of any transcription factor can be used.
Gal4 is a modular protein consisting broadly of a DNA-binding domain and an activation domain.
In accordance with the present invention, a fusión protein of the invention comprises a DNA-binding domain.
A response element recognized by the DNA-binding domain of the first hybrid polypeptide ;.
In a further embodiment, the nucleic acid comprises a nucleotide sequence encoding a DNA-binding domain.
However, the target gene specificity of the DNA-binding domain is relatively unimportant.
In a preferred embodiment of the invention, the nucleic acid molecule further encodes a DNA-binding domain.
These results indicate that a steroid receptor DNA-binding domain is required for efficient repression.
This DNA-binding domain is fused to a nuclease that will cut nearby DNA.
The conserved amino acids corresponding to the putative DNA-binding domain are underlined.
DNA binding domains Any DNA-binding domain can be used in the methods disclosed herein.
Any suitable cleavage domain can be operatively linked to a DNA-binding domain to form a nuclease.
Alternatively, the DNA-binding domain may be derived from a nuclease.
A hybrid receptor will be created with a ligand-binding domain and DNA-binding domain from different sources.
The DNA-binding domain invariably ends with the amino acids Gly-Met.
The SBP domain is a highly conserved DNA-binding domain.
In one embodiment, the DNA-binding domain comprises a zinc finger.
In another embodiment, the protein comprises a DNA-binding domain.
In fact, a DNA-binding domain typical of several regulatory proteins ANN.
The polypeptide can include a myb-like DNA-binding domain.
The polypeptide DNA-binding domain may comprise a Gal4 DNA-binding domain.
The nucleic acid molecule of claim 1 or 2 further encoding a DNA-binding domain.
In this system TXNIP is linked to the DNA-binding domain of the GAL4 transcription factor.
Each receptor contains a ligand-binding domain and a DNA-binding domain.
In this system ADPGK is linked to the DNA-binding domain of the GAL4 transcription factor.
Figure 4 sets forth the point mutational analysis of the hGR DNA-binding domain.
We have shown that the whole DNA-binding domain is encoded by one exon in OR1.
The peptides may have structural complementarity to the DNA-binding domain of p53.
In the case of a ZFN, the DNA-binding domain comprises one or more zinc fingers.
According to another embodiment, the peptides may have structural complementarity to the DNA-binding domain of p53.
The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
Specifically, the methylase was tethered to the DNA-binding domain of GAL4.
The DNA-binding domain of IKZF3 recognizes the core motif of GGGA.
This method involves the fusion of a 3-methyladenine DNA glycosylase to tetR DNA-binding domain.
We determined the crystal structure of ZEBRA 's DNA-binding domain in complex with a methylated ZRE2 site.
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