Examples of 'dose-limiting toxicity' in a sentence
Meaning of "dose-limiting toxicity"
Dose-limiting toxicity refers to the maximum level of toxicity or adverse effects that can be tolerated by an individual or organism when exposed to a particular medication, chemical substance, or treatment. It is the point at which further increase in dosage would result in unacceptable or harmful side effects
How to use "dose-limiting toxicity" in a sentence
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dose-limiting toxicity
No dose-limiting toxicity was seen in clinical trials.
Neurotoxicity is the dose-limiting toxicity of nelarabine.
No dose-limiting toxicity was observed during clinical trials.
Myelosuppression is usually the dose-limiting toxicity.
The dose-limiting toxicity was neutropenia.
Thrombocytopenia has been the dose-limiting toxicity.
The dose-limiting toxicity of this agent is myelosuppression.
No subject experienced a dose-limiting toxicity.
Dose-limiting toxicity with the current schedules was diarrhea.
Myelosuppression is the dose-limiting toxicity of carboplatin injection.
The combination of temsirolimus and sunitinib resulted in dose-limiting toxicity.
The usual dose-limiting toxicity for an alkylating agent is hematopoietic toxicity.
No drug-related serious adverse events occurred and no dose-limiting toxicity was observed.
Dose-limiting toxicity with these compounds is usually urinary tract toxicity.
Gastrointestinal damage is the primary dose-limiting toxicity of a mixture of tegafur and uracil.
See also
Progression from one group to the next is based on the occurrence of dose-limiting toxicity.
The dose-limiting toxicity of oxaliplatin is sensory neuropathy - a characteristic of all DACH-containing platinum derivatives.
This allows a detailed investigation of extramedullary dose-limiting toxicity of the parenteral formulation.
Dose-limiting toxicity consisted of reversible central nervous system depression associated with nausea and hypoacusis.
Preclinical animal studies demonstrated that nephrotoxicity was the major dose-limiting toxicity of cidofovir.
The dose-limiting toxicity of TNF administered to patients is hypotension.
These studies indicated an absence of hemolytic anemia, which is the dose-limiting toxicity of sulofenur.
The dose-limiting toxicity was acute CNS toxicity manifested as sedation and somnolence.
Favorable safety profile with no drug-related serious adverse event and no dose-limiting toxicity.
The dose-limiting toxicity in the Phase I studies was nausea.
Bone marrow suppression was the major dose-limiting toxicity of Paxene.
No dose-limiting toxicity was observed.
Nephrotoxicity Dose-dependent nephrotoxicity is the major dose-limiting toxicity related to administration of cidofovir.
Single doses up to 10 mg / kg intravenously have been administered in a clinical study without dose-limiting toxicity.
Dose-dependent nephrotoxicity is the major dose-limiting toxicity related to administration of cidofovir see section 4.8.
Neutropenia occurred in 13 patients and appeared to be the dose-limiting toxicity.
Neutropenia was the dose-limiting toxicity for Compound 1 and easily managed.
Neutropenia is dose-dependent and a dose-limiting toxicity.
Neurotoxicity is the dose-limiting toxicity associated with nelarabine therapy ( see section 4.4 ).
Doses up to 600 mg have been administered subcutaneously to humans without dose-limiting toxicity.
Hepatic VOD is a dose-limiting toxicity.
Doses up to 180 mg have been administered subcutaneously in clinical trials without dose-limiting toxicity.
MTD determination was based on occurrence of dose-limiting toxicity ( DLT ) in cycle 1.
Single doses up to 6 mg / kg have been administered intravenously in clinical studies without dose-limiting toxicity.
Hematologic, Bone marrow suppression was the major dose-limiting toxicity ofBd-TAXEL.
In controlled trials, single-agent vinorelbine injection was given weekly until progression or dose-limiting toxicity.
Myelosuppression, which is not usually severe with cisplatin, is the dose-limiting toxicity of carboplatin.
Doses up to 2,000 mg have been administered intravenously in clinical trials without dose-limiting toxicity.
In the Phase 1 study, peripheral sensory neuropathy was a dose-limiting toxicity.
In all of these studies, CNS effects represented the dose-limiting toxicity.
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Examples of using Dose-limiting
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No dose-limiting toxicity was seen in clinical trials
Neurotoxicity is the dose-limiting toxicity of nelarabine
Renal toxicity is not usually dose-limiting
Examples of using Toxicity
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Adequate chronic toxicity data not available
Toxicity is a measure of how harmful or poisonous a pesticide is
No clinical signs of toxicity were observed at any dose
