Examples of 'dose-proportional' in a sentence
Meaning of "dose-proportional"
dose-proportional (adjective) - Refers to a type of relationship where the response or effect of something (usually a drug) changes in proportion to the dosage administered
How to use "dose-proportional" in a sentence
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dose-proportional
Systemic exposure of empagliflozin increased in a dose-proportional manner.
Its pharmacokinetics are dose-proportional over the recommended dose range.
Certolizumab pegol plasma concentrations were broadly dose-proportional.
Risperidone plasma concentrations are dose-proportional within the therapeutic dose-range.
The singledose pharmacokinetics of aripiprazole was linear and dose-proportional.
A more than dose-proportional increase in pharmacokinetic exposure was observed in patients with RA.
Valaciclovir pharmacokinetics is not dose-proportional.
Cmax and AUC are approximately dose-proportional following administration of single and multiple doses.
The systemic exposures increased in a dose-proportional manner.
Edoxaban displays approximately dose-proportional pharmacokinetics for doses of 15 mg to 60 mg in healthy subjects.
The single - dose pharmacokinetics of aripiprazole were linear and dose-proportional.
The Cmax and AUC of cannabidiol are close to dose-proportional over the therapeutic dose range.
The single - dose pharmacokinetics of aripiprazole was linear and dose-proportional.
The increase in AUC was generally dose-proportional suggesting linear PK.
The increases for Cmax were slightly greater than directly dose-proportional.
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Pharmacokinetics is dose-proportional and constant over time, with low intra - and inter-subject variability.
Plasma concentrations were shown to be dose-proportional in all age groups.
AUC0-t was dose-proportional for both capsule types.
Plasma AUC of sitagliptin increased in a dose-proportional manner.
Increases in AUC were more than dose-proportional and clearance ( CL ) decreased with increasing dose.
Increases in plasma AUC were slightly greater than dose-proportional.
AUCs were dose-proportional.
Rolapitant displays linear PK with exposures increased in a dose-proportional manner.
Compound 1 showed dose-proportional and time-independcnt behavior.
AUC and Cmax increased with increasing dose but not in a dose-proportional manner.
Cmax ( maximum conc . ) was dose-proportional with respect to dose per intake.
At steady state, the pharmacokinetics of aripiprazole are dose-proportional.
Elbasvir pharmacokinetics were approximately dose-proportional over the range of 5-100 mg once daily.
Ng / ml values were variable and dose-dependent, but appeared only approximately dose-proportional.
In general, anidulafungin concentrations and exposures were dose-proportional for the clinically relevant dose levels.
The dose-proportional kinetics suggested IL-22R saturation at the doses tested.
Steady-state exposure does not increase in a dose-proportional manner.
Cmax is dose-proportional between 5 and 10 mg. Everolimus is a substrate and moderate inhibitor of PgP.
After repeated administration, the pharmacokinetics of macitentan are dose-proportional up to and including 30 mg.
Cmax of DGJ increased in a dose-proportional manner when doses were increased from 50 mg to 150 mg.
However, at doses above 2 mg / kg, the AUC of panitumumab increases in an approximately dose-proportional manner.
The increase in exposure ( Cmax and AUC ) was dose-proportional following repeat dosing.
Secondly, AUC, the main measure of exposure, has generally been found2 to be dose-proportional.
After intramuscular administration, the exposure is approximately dose-proportional in the dose range 50 to 250 mg.
The maximum plasma CI-994 concentrations achieved with increasing dose levels were less than dose-proportional.
Plasma Cmax and AUC of canagliflozin increased in a dose-proportional manner from 50 mg to 300 mg.
Daclatasvir Cmax, AUC, and Cmin increased in a near dose-proportional manner.
Exposures at the 30 mg and 50 mg dose levels were consistent with a dose-proportional increase.
