Examples of 'fc domain' in a sentence
Meaning of "fc domain"
fc domain: Refers to the domain extension .fc, which is a top-level domain in the Domain Name System (DNS). This phrase is typically used in technical contexts related to internet domain names
How to use "fc domain" in a sentence
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fc domain
Fc domain modifications identified as altering effector function are disclosed above.
The constant region domain is typically an Fc domain.
The Fc domain can be from any immunoglobulin.
In a further particular embodiment the Fc domain is human.
With the Fc domain of a human antibody.
A third modality in such a bispecific antibody is the Fc domain.
The Fc domain may be monomeric or heterodimeric.
Preferred is an immunoglobulin Fc domain which can be used as a carrier.
The Fc domain of an antibody or antibody fragment.
The disclosure encompasses diabody molecules comprising an Fc domain.
Decrease binding of said Fc domain to FcYRIIB.
In an embodiment it comprises one or more fragments of the Fc domain.
The Fc domain of an antibody is required for the activation of complement.
A variable domain may be fused to an Fc domain.
An Fc domain is one preferred vehicle.
See also
The antibody polypeptides of the invention comprise an Fc domain.
An Fc domain is the preferred vehicle.
The second polypeptide fusión partner comprises an immunoglobulin Fc domain.
An Fc domain includes the hinge region of the heavy chain.
The molecule may comprise a chimeric Fc domain as described herein.
The Fc domain is shown in bold.
The recombinant follistatin protein of the invention is fused to an Fc domain.
A chimeric Fc domain can also contain a chimeric hinge region.
Preferably the bispecific antibody according to the disclosure is devoid of a Fc domain.
The Fc domain optionally is capable of effector functions such as complement binding.
Preferably the bispecific antibody according to the invention comprises a Fc domain.
An Fc domain can contain one or all of the domains described above.
Preferably the bispecific antibody according to the invention is devoid of a Fc domain.
An Fc domain of an immunoglobulin heavy chain is a preferred domain for fusión proteins.
Preferred is a recombinant immunoglobulin Fc domain derived from the human Fc domain in microorganisms.
The Fc domain facilitates affinity purification and protein detection by immunoblotting or immunohistochemistry.
Other approaches include the genetic fusión of an Fc domain to the therapeutic GH protein.
Any suitable Fc domain known in the art or described herein may be used.
The recombinant follistatin protein of the invention is fused to the Fc domain vía a linker.
The two subunits of the Fc domain are capable of stable association with each other.
In certain embodiments a linker domain can be used to connect a UTI domain to a Fc domain.
Purification of the expressed Fc domain containing polypeptide can be performed by any standard method.
Examples of polypeptide fusión partners include serum albumin and the antibody Fc domain.
Fc Domain Immunoglobulins of IgG class are among the most abundant proteins in human blood.
The orientation of the binding domain relative to the Fc domain dictates the ADCC activity.
An Fc domain is comprised of two Fc domain monomers.
In particular embodiments the Fc domain is a human Fc domain.
The Fc domain may comprise native or variant Fc sequences.
Activation occurs when the Fc domain is bound by a cognate Fc receptor.
An Fc domain as used herein encompasses native Fc and Fc variant molecules.
The association of two Fc domain monomers creates one Fc domain.
The modified LCAT protein of the invention comprises an IgG Fc domain.
The limits of an Fc domain are set out in Kabat et al.
UTI fusión proteins include an Fc domain.
Fc Domain Variants The polypeptides of the present invention have variant Fc domains.
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