Examples of 'fc domains' in a sentence
Meaning of "fc domains"
FC domains: In the context of the internet and web technology, FC domains may refer to Fully-Qualified Domain Names, which are complete website addresses that specify the exact location of web pages or resources on the internet. FC domains are essential for accurately navigating the web and accessing specific online content
How to use "fc domains" in a sentence
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fc domains
Fc domains can also increase bioavailability of an antibody in circulation following administration to a subject.
Oligosaccharides of IgG are bound to Fc domains in the immunogloblin molecule.
Certain Fc domains of the disclosure are engineered to comprise a chimeric hinge.
Such antibody activities exerted vía Fc domains are called effector activities.
The antibodies of the present invention have variant Fc domains.
Exemplary amino acid modifications of Fc domains also are provided elsewhere herein.
Display of scFvs on the surface of mammalian cells fused to Fc domains.
Particularly suitable Fc domains include those derived from human or humanized antibodies.
Examples of additional multimerization domains can include leucine zippers or Fc domains.
The noncovalent bonding of the Fc domains is sufficient to hold together the dimer.
The polypeptides of the present invention may have variant Fc domains.
One is that certain immunoglobulin Fc domains participate in effector functions of the immune system.
This includes making fusión proteins with albumin or Fc domains and PEGylation.
The individual Fc domains and partial Fc domains may also be humanized.
The term encompasses heterodimeric Fc regions where each of the constituent Fc domains is different.
See also
Most available mAbs incorporate human Fc domains that do not stimulate immune responses.
Multimerisation of Fc binding regions generates molecules having higher avidity interactions with Fc domains.
Example salting out data for mAbs with different Fc domains or different Fab domains.
Such a complex may be stabilized by disulfide bond formation between the immunoglobulin Fc domains.
In one embodiment, the Fc domains may be of different types.
Multimerization domains include Fc domains.
Fc domains bind to the FcgammaR at the position indicated in Figure 1.
Fc Domain Variants The polypeptides of the present invention have variant Fc domains.
Polyhistidine peptides, antibody Fc domains to facilitate the process.
None of the protease variants or wild-type cleave the Fc domains.
However, receptors for Fc domains are present on many cell types.
In other embodiments, diabody molecules comprising Fc domains may be tetramers.
Examples of Fc domains are shown below,.
Tandem diabodies have two binding sites for each antigen, but no Fc domains.
Fc domains bind to the FcgammaR at the position indicated in FIG . 1.
Example 1, Generation of bivalent monospecific Antibodies with Heterodimer Fc domains.
FIG . 3 provides sequences of various Fc domains provided herein.
Example 2, Purification of bivalent monospecific Antibodies with Heterodimer Fc domains.
Additionally all Fc domains used were wild-type IgG1 Fc domains.
Such preferred human FcRn-binding regions include, for example, antibody Fc domains.
Fc domains are known to mediate Fc effector functions, as described in Section 3.5.
These antibodies all bind human NKp46, are of murine origin and have murine Fc domains.
In other embodiments, DART ™ molecules comprising Fc domains may be tetramers.
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