Examples of 'fc polypeptide' in a sentence
Meaning of "fc polypeptide"
FC polypeptide: a type of polypeptide molecule that contains a folded chain of amino acids and plays a role in various biological functions, such as protein synthesis or cell signaling
How to use "fc polypeptide" in a sentence
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fc polypeptide
In some embodiments the fusión partner is a human Fc polypeptide.
Preferred polypeptides comprise an Fc polypeptide derived from a human IgGI antibody.
It is disclosed that the fusión partner is a mouse Fc polypeptide.
Recovering the monomeric Fc polypeptide from the host cell culture.
It is disclosed that the fusión partner is a rat Fc polypeptide.
The single chain Fc polypeptide may have one or more effector molecules attached.
Within one embodiment the affinity tag is an immunoglobulin Fc polypeptide.
Fc variants may be constructed in a parent Fc polypeptide irrespective of its context.
In other embodiments the the fusión partner is a mouse Fc polypeptide.
An Fc polypeptide as described herein also includes Fc polypeptide variants.
In other embodiments the the fusión partner is a rat Fc polypeptide.
The Fc polypeptide may also be a mutein Fc polypeptide as described herein.
Embodiments of the invention further include methods of preparing a monomeric Fc polypeptide.
The immunoglobulin Fc polypeptide is modified to enhance FcRn binding ;.
Any of these FGFR fusión proteins may comprise an Fc polypeptide.
See also
In some embodiments, the Fc polypeptide is modified to enhance FcRn binding.
In one aspect, the heterologous polypeptide is an Fc polypeptide or domain.
The Fc polypeptide preferably is fused to the C-terminus of a catalytic or targeting domain.
In one embodiment said human IgG Fc polypeptide is IgG4.
In one embodiment, a first Fc polypeptide and a second Fc polypeptide meet / interact at an interfaz.
In one embodiment, the heterologous polypeptide is an Fc polypeptide or domain.
In some embodiments, an Fc polypeptide does not comprise a functional or wild type hinge sequence.
In one embodiment, at least one polypeptide tag is an Fc polypeptide.
Preferred polypeptides comprise an Fc polypeptide derived from a human IgG1 antibody.
For example, an antibody contains an Fc polypeptide.
The monomeric Fc polypeptide of claim 1, wherein said polypeptide comprises an antibody variable domain.
In particular embodiments, the Fc polypeptide is an IgG.
An expression vector according to claim 17 wherein the affinity tag is an immunoglobulin Fc polypeptide.
A monomeric antibody comprising the monomeric Fc polypeptide of claim 4 and an antibody light chain.
Within one embodiment, the polypeptide further comprises an immunoglobulin Fc polypeptide.
The monomeric Fc polypeptide of claim 3, wherein said polypeptide comprises an antibody heavy chain.
In one embodiment, the multimer comprises an Fc polypeptide or a leucine zipper.
A single chain Fc polypeptide according to claim 7 wherein the linker comprises a cysteine residue.
An isolated nucleic acid encoding the monomeric Fc polypeptide of claim 1.
Alternatively, the native Fc polypeptide from which the mutein was derived may be employed.
Deletion variants, therefore, include all fragments of an Fc polypeptide sequence.
A separate Fc polypeptide is attached to the C-terminus of AcPI.
An expression vector comprising a nucleic acid encoding the monomeric Fc polypeptide of claim 1.
Exemplary Fc polypeptides comprise an Fc polypeptide derived from a human IgG1 antibody.
Said Fc region is formed through the complexing ( multimerizing ) of separate Fc polypeptide sequences.
Alternatively, the Ig Fc polypeptide may comprise a mutant Ig polypeptide.
A host cell comprising a nucleic acid encoding the monomeric Fc polypeptide of claim 1.
In some embodiments, the Ig Fc polypeptide comprises a wild-type Ig Fc polypeptide.
The nucleic acid molecule of claim 5, wherein the heterologous protein is an Fc polypeptide.
Alternatively, if the single-chain Fc polypeptide has a long half life e . g.
The pharmaceutical compositions preferably comprise a therapeutically effective amount of the single-chain Fc polypeptide.
In some cases, the Ig Fc polypeptide is an IgG3 Fc polypeptide.
In one embodiment, the affinity tag comprises one polypeptide tag, such as a mutein Fc polypeptide.
The monomeric Fc polypeptide of claim 2, wherein said polypeptide comprises a CH1 domain.
In one embodiment said Fc variant of a human IgG Fc polypeptide is an Fc-fusion.
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