Examples of 'heavy and light chain' in a sentence
Meaning of "heavy and light chain"
In immunology, heavy and light chains refer to the two types of polypeptide chains that make up an antibody molecule. The heavy chain determines the class or isotype of the antibody, while the light chain is responsible for antigen recognition. Together, they form the basic structure of an antibody
How to use "heavy and light chain" in a sentence
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heavy and light chain
Heavy and light chain are not linked vía a disulfide bond.
Immunoglobulins may have both a heavy and light chain.
Regions outside heavy and light chain variable regions are underlined.
Sections e to g cover preparation of the heavy and light chain repertoires.
The amplified heavy and light chain variable regions were sequenced.
Antibody molecules consist of both heavy and light chain components.
Each heavy and light chain also has intrachain disulfide bridges.
Plasmid identification numbers for various heavy and light chain plasmids.
The heavy and light chain nucleotides may be inserted in one vector.
Seqwright sequencing services sequenced the heavy and light chain clones.
The sequences of the heavy and light chain frameworks are known in the art.
Hemibodies can be constructed using the provided heavy and light chain components.
Chimeric heavy and light chain constructs are prepared utilizing the cDNA sequences.
This procedure provides for equal expression of heavy and light chain polypeptides.
Each heavy and light chain may comprise a variable and a constant domain.
See also
Under reducing conditions the conjugate dissociated in to heavy and light chain fragments.
All such combinations of heavy and light chain are encompassed by the present invention.
A single electroporation was sufficient to achieve integration of both heavy and light chain genes.
The variable regions of the heavy and light chain bind to a specific antigen.
The heavy and light chain genes were cloned into a mammalian expression vector.
An antibody has a recognized structure that includes an immunoglobulin heavy and light chain.
Each heavy and light chain pair is linked through an interchain disulfide bond.
This is done independently for both the heavy and light chain variable domain sequences.
The relevant heavy and light chain plasmids were paired for expression in mammalian cells.
This is done independently for both the heavy and light chain variable region sequences.
Pseudogenes for heavy and light chain were amplified and were eliminated by standard sequence analyses.
The promoter may be the same or different for the heavy and light chain.
The cDNAs encoding heavy and light chain variable domains are isolated from a hybridoma.
Such dual specific ligands can comprise combinations of heavy and light chain domains.
In some instances the heavy and light chain components may be encoded by a single vector.
The resulting transformants constitute combined library of heavy and light chain fragments in fdTetSXNS.
The variable heavy and light chain components is preferably present on a single peptide chain.
It was clear from the result that both heavy and light chain are efficiently synthesised.
The heavy and light chain variable region sequences are shown in the sequence listing.
Each clone name and its heavy and light chain germline is given below.
Heavy and light chain immunoglobulin cDNA expression libraries are created in bacteriophage lambda vectors.
Both chimeras are made of identical heavy and light chain but carry different peptides.
The heavy and light chain constructs can be placed in the same or separate vectors.
Specific primers are used to amplify variable heavy and light chain domain nucleic acids.
Each heavy and light chain also has regularly spaced invachain disulfide bridges.
Clones were established that tested positive for the presence of assembled heavy and light chain.
Positive clones for the heavy and light chain were picked for sequencing analysis.
The invention further relates to a nucleic acid set encoding a respective heavy and light chain set.
An antibody consists of heavy and light chain polypeptides which associate to produce a functional molecule.
Five hybridomas were selected for sequence analysis of their Ig heavy and light chain genes.
The chimeric heavy and light chain genes are genomic constructs and expressed in mammalian cells.
VH and VI are antibody variable heavy and light chain respectively.
Heavy and light chain immunog lobulin cDNA expression libraries are created in bacteriophage lambda vectors.
Amino acid sequences of the heavy and light chain WT and variant constant regions.
The heavy and light chain variable region sequences from the Aximab hybridoma were determined.
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