Examples of 'heavy chain variable region' in a sentence
Meaning of "heavy chain variable region"
heavy chain variable region: In the context of biology or immunology, it refers to a specific part of an antibody molecule
How to use "heavy chain variable region" in a sentence
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heavy chain variable region
The binding domain polypeptide can be a heavy chain variable region or a light chain variable region.
The heavy chain variable region can be a humanized or human variable heavy chain variable region.
The light chain variable region is separated from heavy chain variable region by a linker region.
A heavy chain variable region and the constant region of another subclass can be directly linked.
The above first and second polypeptides may additionally comprise an antibody heavy chain variable region.
Chimeric heavy chain variable region and signal nucleotide and amino acid sequences are provided.
The antigen binding domain may comprise a light chain variable region and a heavy chain variable region.
Harvesting the immunoglobulin heavy chain variable region and the immunoglobulin light chain variable region.
An antibody or antibody fragment according to claim 1, which comprises a heavy chain variable region having.
A humanized heavy chain variable region is illustrated in Fig.
The antibody is a humanized antibody comprising a heavy chain variable region shown in Fig.
A humanized heavy chain variable region and signal sequences are illustrated in Fig.
Some humanized antibodies comprise a heavy chain variable region shown in Fig.
The synthetic heavy chain variable region nucleotide and amino acid sequences are provided in Fig.
In additional embodiments, only the heavy chain variable region is required.
See also
A heavy chain variable region comprising the following CDRs,.
In a specific embodiment, the mouse comprises a humanized heavy chain variable region gene segment.
The first row shows the heavy chain variable region numbering using the Kabat system.
Nucleotide sequence of the gene for the humanized anti-Tac heavy chain variable region gene.
CDRs can be located in a heavy chain variable region sequence in the following way.
Heavy chain variable region for Impilimumab,.
Figure 1 shows the cDNA sequence coding for a murine heavy chain variable region having anti-PLAP specificity.
A heavy chain variable region comprising the amino acid sequence,.
A-3 Amplification and fragmentation of cDNA encoding a mouse heavy chain variable region.
An antibody heavy chain variable region comprising,.
A humanized antibody of any of claims 1 to 5 comprising a heavy chain variable region shown in Fig.
In an embodiment, the heavy chain variable region is preceded by a signal peptide.
It was likely that this fragment contained the 7E3 heavy chain variable region gene.
The sequence of the heavy chain variable region of this antibody is, or.
Nucleotide and deduced amino acid sequences of reshaped human F19 heavy chain variable region versions a to e.
The heavy chain variable region of several independent clones of pRR62 were sequenced.
To construct the FR-patched heavy chain variable region sequence SEQ ID no.
And a heavy chain variable region comprising the following amino acid sequence,.
SEQ ID NO, 9 corresponds to the nucleotide sequence of the heavy chain variable region.
And having at least one heavy chain variable region comprising the following CDRs,.
SEQ ID NO, 1 corresponds to the amino acid sequences of the heavy chain variable region.
The immunoglobulin heavy chain variable region comprises an amino acid sequence selected from,.
Fig . 30 depicts the construction of a synthetic heavy chain variable region.
Said heavy chain variable region amino acid sequence is covalently paired vÃa a peptide linker ; or.
Fig . 5 sets forth a series of humanized heavy chain variable region sequences.
The heavy chain variable region and the light chain variable region each contain 3 CDRs.
The polypeptide of claim 8, wherein the heavy chain variable region contains tyrosine at position 95.
VH = heavy chain variable region encoding sequence.
The mouse of claim 3, wherein the humanized immunoglobulin heavy chain variable region locus comprises,.
A polynucleotide encoding a heavy chain variable region and / or a light chain variable region of the antibody ; and.
An anti-VEGF antibody, wherein the antibody is bispecific and the heavy chain variable region comprises,.
SAYTSSDTLV ; and a heavy chain variable region comprising the.
Also provided is a monoclonal antibody that comprises the heavy chain variable region of 34A3.
A heavy chain variable region comprising the amino acid sequence as shown in Figure 1A ; and.
Figure 4, Sequence alignment of the heavy chain variable region.
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