Examples of 'heavy chain variable domain' in a sentence
Meaning of "heavy chain variable domain"
heavy chain variable domain: A component of antibodies that functions in binding to specific antigens
How to use "heavy chain variable domain" in a sentence
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heavy chain variable domain
E heavy chain variable domain nucleotide sequence.
Such residues are typically derived from a heavy chain variable domain.
In the heavy chain variable domain there is an unusual feature in the framework region.
A heavy chain refers to any polypeptide that a heavy chain variable domain.
VHH denotes heavy chain variable domain of a heavy chain immunoglobulin.
A common denominator of such specific binding bodies is the presence of a heavy chain variable domain.
A heavy chain variable domain comprising,.
In one embodiment VH represents a heavy chain variable domain.
A heavy chain variable domain of the amino acid sequence,.
In one embodiment Vyy represents a heavy chain variable domain.
The cloned rat heavy chain variable domain ( RaVHCAMP ) was also expressed as above.
A method according to claim 7 wherein each polypeptide is an antibody heavy chain variable domain.
In one embodiment residue 78 of the heavy chain variable domain is replaced with alanine.
In particular embodiments, the immunoglobulin single variable domain is a heavy chain variable domain.
That is, the heavy chain variable domain forms the complete antigen-binding site.
See also
A VL domain sequence or a suitable fragment thereof, or heavy chain variable domain sequences e . g.
The variant has a heavy chain variable domain comprising the following hypervariable region amino acid sequences,.
An aglycosylated antibody according to Claim 9 having a heavy chain variable domain which comprises.
The heavy chain variable domain comprises one or more CDR regions, preferably a CDRH3 region.
Disclosed herein are antibodies comprising a heavy chain variable domain having the following sequence,.
Each fragment contains a heavy chain variable domain ( VH ) concatenated to a light chain variable domain ( VL ).
A VL-sequence or a suitable fragment thereof ; or a heavy chain variable domain sequence e . g.
Optionally, the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO, 13.
This method is for obtaining an immunoglobulin heavy chain variable domain with a RT-GSP-PCR reaction.
Rat 23E12 heavy chain variable domain amino acid with signal sequence.
The polypeptide sequence of the heavy chain variable domain of mAQC2 is,.
Figure 2 depicts the amino acid sequence of the 2F8 heavy chain variable domain.
In more particular embodiments, the heavy chain variable domain is a human heavy chain variable domain.
In some aspects, the target antibody sequences comprise immunoglobulin ( Ig ) heavy chain variable domain sequences.
A preferred anti-VEGF antibody heavy chain variable domain comprises the amino acid sequence,.
A light chain variable domain having the sequence, and / or a heavy chain variable domain having the sequence,.
Rat 23E12 heavy chain variable domain DNA with signal sequence.
A first nucleic acid molecule encoding the heavy chain variable domain of claim 16 ;.
The antibody may comprise a heavy chain variable domain framework region 1 of SEQ ID NO, 25.
A ligand, antibody or fragment thereof according to Claim 6, having a heavy chain variable domain which comprises.
A VL-sequence, or heavy chain variable domain sequences e . g.
In one embodiment, the anti-EphB2 antibody comprises a heavy chain variable domain having the sequence,.
A VI domain sequence or a heavy chain variable domain sequence e . g.
The antibody that binds to CD22 comprises a heavy chain variable domain of SEQ ID NO, 16.
The amino acid translation of the heavy chain variable domain sequence is presented in Figure 3.
In one embodiment, the antibody comprises a heavy chain variable domain of SEQ ID NOs, 9 or 10.
A fourth domain VHA being a heavy chain variable domain specific for CD3, wherein.
Preferably, the substitution ( s ) are in the heavy chain variable domain of the parent antibody.
Disclosed herein is an antibody comprising a heavy chain variable domain having the following sequence,.
In various embodiments, the antibody comprises a heavy chain variable domain that contains a rearranged human.
A VH1 domain comprising a binding region of a heavy chain variable domain of the first immunoglobulin ; and.
The antibody may comprise a heavy chain variable domain of SEQ ID NO, 10.
A second domain VHB being a heavy chain variable domain specific for CD19 ;.
A VL-sequence ; or of a heavy chain variable domain sequence e . g.
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