Examples of 'heavy chain variable' in a sentence
Meaning of "heavy chain variable"
heavy chain variable - This term may refer to a scientific or mathematical variable that has a significant impact or influence on the outcome or results of an experiment, equation, or system
How to use "heavy chain variable" in a sentence
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heavy chain variable
E heavy chain variable domain nucleotide sequence.
Such residues are typically derived from a heavy chain variable domain.
Light chain and heavy chain variable regions were amplified in separate reactions.
A heavy chain refers to any polypeptide that a heavy chain variable domain.
In the heavy chain variable domain there is an unusual feature in the framework region.
Typically the chimeric antibody comprises both light and heavy chain variable domains.
Any of the heavy chain variable regions may be combined with a suitable human constant region.
Typically the chimaecic antibody comprises both light and heavy chain variable domains.
The heavy chain variable region can be a humanized or human variable heavy chain variable region.
Typically the chimaeric antibody comprises both light and heavy chain variable domains.
A heavy chain variable region and the constant region of another subclass can be directly linked.
A common denominator of such specific binding bodies is the presence of a heavy chain variable domain.
The binding domain polypeptide can be a heavy chain variable region or a light chain variable region.
The heavy chain variable regions of such antibodies can be derived from any selected antibodies.
Polynucleotide and polypeptide sequences of particular light and heavy chain variable domains are shown below.
See also
heavy chain constant
heavy chain constant region
heavy chain variable domain
heavy chain variable region
heavy chain constant region
heavy chain variable domain
heavy chain variable region
Chimeric heavy chain variable region and signal nucleotide and amino acid sequences are provided.
The light chain variable region is separated from heavy chain variable region by a linker region.
A humanized heavy chain variable region is illustrated in Fig.
Typically the antigen binding region comprises both light and heavy chain variable domains.
Harvesting the immunoglobulin heavy chain variable region and the immunoglobulin light chain variable region.
The above first and second polypeptides may additionally comprise an antibody heavy chain variable region.
VHH denotes heavy chain variable domain of a heavy chain immunoglobulin.
The antigen binding domain may comprise a light chain variable region and a heavy chain variable region.
A humanized heavy chain variable region and signal sequences are illustrated in Fig.
Single chain antibodies comprise the light and heavy chain variable regions linked by a flexible linker.
The synthetic heavy chain variable region nucleotide and amino acid sequences are provided in Fig.
Preferably the ScFv fragment comprises a linker sequence between light chain and heavy chain variable regions.
CDRs can be located in a heavy chain variable region sequence in the following way.
Heavy chain variable part, nucleotide sequence.
In one embodiment VH represents a heavy chain variable domain.
An antibody heavy chain variable region comprising,.
In one embodiment Vyy represents a heavy chain variable domain.
A heavy chain variable domain comprising,.
PVHf is used as an expression cassette for heavy chain variable sequences.
The first row shows the heavy chain variable region numbering using the Kabat system.
Preferably, the antibody contains one or two heavy chain variable domains.
A heavy chain variable domain of the amino acid sequence,.
Some humanized antibodies comprise a heavy chain variable region shown in Fig.
A heavy chain variable region comprising the following CDRs,.
VH amplification primers designed to amplify human heavy chain variable regions are contemplated.
A heavy chain variable region comprising the amino acid sequence,.
The antibody is a humanized antibody comprising a heavy chain variable region shown in Fig.
The heavy chain variable region of several independent clones of pRR62 were sequenced.
Amino acid sequence of heavy chain variable region,.
And a heavy chain variable region comprising the following amino acid sequence,.
In additional embodiments, only the heavy chain variable region is required.
That is, the heavy chain variable domain forms the complete antigen-binding site.
A method according to claim 7 wherein each polypeptide is an antibody heavy chain variable domain.
In an embodiment, the heavy chain variable region is preceded by a signal peptide.
In particular embodiments, the immunoglobulin single variable domain is a heavy chain variable domain.
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