Examples of 'histone deacetylase' in a sentence
Meaning of "histone deacetylase"
Histone deacetylase: Histone deacetylase is an enzyme that removes an acetyl group from histone proteins, which can affect gene expression and chromatin structure
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- Any of a class of enzymes that remove acetyl groups from lysine amino acids in proteins, especially the histone proteins of the nucleus
How to use "histone deacetylase" in a sentence
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histone deacetylase
Squaric acid derivatives as inhibitors of histone deacetylase.
Inhibition of histone deacetylase as a treatment for cardiac hypertrophy.
Compounds for the inhibition of histone deacetylase.
Histone deacetylase inhibitors and their use in therapy.
Spirocyclic derivatives as histone deacetylase inhibitors.
Histone deacetylase inhibitors.
A new class of histone deacetylase inhibitors.
The effect is mediated in part by inhibition of histone deacetylase.
A variety of inhibitors for histone deacetylase have been identified.
It would be highly desirable to have novel inhibitors of histone deacetylase.
A potential role for histone deacetylase inhibitors is under study.
This invention relates to the inhibition of histone deacetylase.
Activity of histone deacetylase inhibitors.
Currently six compounds as inhibitors of histone deacetylase are known.
Inhibition of the histone deacetylase can be in a cell or a multicellular organism.
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This gene product belongs to the histone deacetylase family.
Histone deacetylase inhibitors alter the histone acetylation profile of chromatin.
It would thus be desirable to have new inhibitors of histone deacetylase.
It possesses histone deacetylase activity and represses transcription when tethered to a promoter.
Step of treating a test cell with a histone deacetylase inhibitor.
Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy.
The invention provides new inhibitors of histone deacetylase enzymatic activity.
The histone deacetylase can also be derived from a protozoal or fungal source.
The compounds of this invention are useful in the inhibition of histone deacetylase.
The histone deacetylase inhibitor to be used for this step is as mentioned above.
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase.
Use of histone deacetylase inhibitors for increasing therapeutic gain in radiotherapy and chemotherapy.
Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase.
Measurement of the enzymatic activity of a histone deacetylase can be achieved using known methodologies.
Histone deacetylase can reverse the process and can serve to repress gene expression.
The problem to be solved is to provide histone deacetylase inhibitors with high enzymatic activity.
The histone deacetylase inhibitor agents can be brought in the form of pharmaceutically acceptable salts.
Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors.
Heterocyclicalkyl derivative compounds as selective histone deacetylase inhibitors and pharmaceutical compositions comprising the same.
There is only limited data published regarding specificity of these histone deacetylase inhibitors.
Histone deacetylase activity from crude nuclear extract derived from HeLa cells was used for screening.
Such epigenetic therapy may involve the use of histone deacetylase inhibitors or methylation inhibitors.
Histone deacetylase inhibitors rescue progressive neuronal degeneration and lethality in Drosophila.
The compounds of the present invention show good in vitro histone deacetylase inhibiting enzymatic activity.
The therapeutic use of histone deacetylase inhibitors to treat tumours is described in Anticancer Res.
In one embodiment, such a chemotherapeutic agent may be a histone deacetylase inhibitor.
A negative control without histone deacetylase activity and a positive control without HDAC inhibitor are treated likewise.
The term " compartment " denotes a particle containing a histone deacetylase inhibitor.
Epigenetic control using histone deacetylase inhibitors, such as trichostatin a, is a promising cancer therapy.
The best-explored line of inquiry has examined histone deacetylase inhibitors.
Histone deacetylase inhibitors are a class of molecules provided with antineoplastic and anti-inflammatory activity.
Compounds of the present invention may show excellent histone deacetylase inhibiting enzymatic and cellular activity.
In the third aspect, the invention provides a method of inhibiting histone deacetylase.
The MITR protein lacks the histone deacetylase catalytic domain.
Use of histone deacetylase inhibitors for the care of philadelphia-negative myeloproliferative syndromes.
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Examples of using Deacetylase
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Squaric acid derivatives as inhibitors of histone deacetylase
Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
Compounds for the inhibition of histone deacetylase
Examples of using Histone
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Histone acetylation is also an important process in transcription
The inhibitor inhibits histone methylase activity
Histone modifications modulate the packing of chromatin
