Examples of 'deacetylase' in a sentence
Meaning of "deacetylase"
deacetylase (adjective) - Deacetylase is a term used in biochemistry to describe enzymes that remove acetyl groups from proteins. These enzymes play a significant role in various cellular processes
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- Any of several classes of enzyme that remove acetyl groups from proteins
How to use "deacetylase" in a sentence
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deacetylase
Squaric acid derivatives as inhibitors of histone deacetylase.
Inhibition of histone deacetylase as a treatment for cardiac hypertrophy.
Compounds for the inhibition of histone deacetylase.
Histone deacetylase inhibitors and their use in therapy.
Spirocyclic derivatives as histone deacetylase inhibitors.
Histone deacetylase inhibitors.
This immunoadsorbent was used for chitin deacetylase purification.
Inhibition of the histone deacetylase can be in a cell or a multicellular organism.
The effect is mediated in part by inhibition of histone deacetylase.
A new class of histone deacetylase inhibitors.
The substrate is incubated with the acetylase or deacetylase.
A potential role for histone deacetylase inhibitors is under study.
A peptide of interest inhibits an enzymatic activity of tubulin deacetylase.
A variety of inhibitors for histone deacetylase have been identified.
It would be highly desirable to have novel inhibitors of histone deacetylase.
See also
Activity of histone deacetylase inhibitors.
This invention relates to the inhibition of histone deacetylase.
An agent that inhibits tubulin deacetylase is administered by any route of administration.
Currently six compounds as inhibitors of histone deacetylase are known.
Histone deacetylase inhibitors alter the histone acetylation profile of chromatin.
This gene product belongs to the histone deacetylase family.
A deacetylase is an enzyme that releases an acetyl group from an acetylated peptide.
It would thus be desirable to have new inhibitors of histone deacetylase.
It possesses histone deacetylase activity and represses transcription when tethered to a promoter.
Step of treating a test cell with a histone deacetylase inhibitor.
Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy.
The invention provides new inhibitors of histone deacetylase enzymatic activity.
The histone deacetylase can also be derived from a protozoal or fungal source.
The compounds of this invention are useful in the inhibition of histone deacetylase.
A preferred source for chitin deacetylase is the cell wall of fungal mycelia.
Subsequently said acidified fraction obtained is contacted with a chitin deacetylase.
The histone deacetylase inhibitor to be used for this step is as mentioned above.
The specificity of the antiserum produced was analyzed in a chitin deacetylase inhibition assay.
The activity of a deacetylase enzyme are determined using the methods described herein.
The invention further provides methods of modulating tubulin deacetylase activity in a cell.
Several deacetylase inhibitors have been previously synthesized and used for other purposes.
A biologically active agent of the invention modulates a level or an activity of a tubulin deacetylase.
The supernatant extract having deacetylase activity was aliquotted and frozen for storage.
The IgG was coupled by the method described for chitin deacetylase coupling.
Use of histone deacetylase inhibitors for increasing therapeutic gain in radiotherapy and chemotherapy.
Another suitable agent for reducing an activity of a tubulin deacetylase is a peptide aptamer.
A single deacetylase inhibitor may be administered or combinations of various deacetylase inhibitors may be administered.
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase.
Measurement of the enzymatic activity of a histone deacetylase can be achieved using known methodologies.
Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase.
The problem to be solved is to provide histone deacetylase inhibitors with high enzymatic activity.
Histone deacetylase can reverse the process and can serve to repress gene expression.
Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors.
The histone deacetylase inhibitor agents can be brought in the form of pharmaceutically acceptable salts.
There is only limited data published regarding specificity of these histone deacetylase inhibitors.
