Examples of 'humanised antibody' in a sentence
Meaning of "humanised antibody"
humanised antibody - An antibody used in treatments that has been modified to resemble natural human antibodies
How to use "humanised antibody" in a sentence
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humanised antibody
Humanised antibody fragments represent preferred agents.
There are four general steps to produce a humanised antibody.
The humanised antibody can be recovered and purified.
The antibody may also be a chimeric or a humanised antibody.
Construction of humanised antibody vectors.
An antibody of the invention may be a human antibody or a humanised antibody.
The antibody may be a human or humanised antibody or fragment thereof.
The antibody according to any preceding item which is a chimeric or humanised antibody.
The antibody may also be a humanised antibody or a fragment of a humanised antibody.
Culturing the transfected cell by conventional techniques to produce the humanised antibody.
The delivery component of the immunotoxin is a humanised antibody according to the present invention.
The humanised antibody can be prepared using any suitable recombinant expression system.
Antibody molecules are preferably human or humanised antibody molecules.
X Use of a humanised antibody or chain produced according to statement T or U in medicine.
This yielded the final expression vector for the humanised antibody version VHQ.
See also
These chimerised or humanised antibody formats allow for monospecific / bivalent combinations.
Alternatively, the antibody may be a humanised antibody.
The humanised antibody further comprises human constant heavy and light chain domains, where present.
Preferably, the antibody is a humanised antibody.
A heavy chain of a humanised antibody of any one of claims 1 to 11 or.
In one embodiment, the antibody is a human or humanised antibody.
Conveniently, the framework regions of the humanised antibody are derived from a human IgG monoclonal antibody.
More preferably, the antibody is a human or humanised antibody.
The HAM may comprise a chimeric humanised antibody or a CDR-grafted humanised antibody.
Accordingly, in one embodiment the antibody of the invention is a humanised antibody.
Thus, the HAM may comprise a chimeric humanised antibody or a CDR-grafted humanised antibody.
A composition of matter according to claim 1, wherein said antibody is a humanised antibody.
Cells were incubated with rat or humanised antibody for 30 minutes on ice.
Preferably the anti-IgE antibody of the invention is a human or humanised antibody.
A composition comprising an anti-CTLA4 humanised antibody of claim 1 or a polynucleotide encoding the antibody.
A composition according to claim 1, which is a human or humanised antibody molecule.
These chimerised or humanised antibody formats are of monospecific / bivalent, bispecific / monovalent and biepitopic / monovalent types.
In a first aspect, the invention provides as humanised antibody as claimed in claim 1.
The humanised antibody was expressed in the murine myeloma line Sp2/0.
A composition according to claim 1, wherein the antibody molecule is a human or humanised antibody molecule.
The cytotoxic conjugate comprises the humanised antibody of claims 1-9 and a cytotoxic agent.
Preferably, the antibody molecules used in the disclosure are human or humanised antibody molecules.
Preferably, the humanised antibody is Rituximab or an antibody fragment thereof, e.g. a Fab fragment.
Retention of this residue provided improved potency of the humanised antibody as shown in Example 3.
The resulting humanised antibody was tested for CD38 binding, with negative results.
The DNA sequences of the V-regions were used to design humanised antibody.
This article discloses the 4D5 humanised antibody used in the CDR grafting.
The composition of claim 1, wherein the antibody is a humanised antibody.
A humanised antibody according to claim 23.
A polynucleotide encoding an anti-CTLA4 humanised antibody of claim 1.
Figure 9 shows a model of the V-domain of humanised antibody.
A therapeutic or diagnostic composition comprising a CDR-grafted humanised antibody according to claim 1 or claim 2.
Use according to Claim 1, wherein said antibody is a humanised antibody.
They may also be of different origin ( e.g. a human or humanised antibody and a murine antibody ).
Use according to claim 1-5, wherein the antibody is a humanised antibody.
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