Examples of 'hypervariable' in a sentence
Meaning of "hypervariable"
Hypervariable (adjective): Referring to a high degree of variability or change, often used in genetics to describe regions of genes that exhibit a lot of variation
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- Having a high degree of variability.
How to use "hypervariable" in a sentence
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hypervariable
Hinge regions are the hypervariable regions of a flagellin.
The hypervariable regions are underlined and in bold.
Consists of one of the hypervariable regions or loops.
The hypervariable regions can be cloned and sequenced.
Genotypic analysis of two hypervariable human cytomegalovirus genes.
The hypervariable region is important for immune recognition.
Preferably monoclonal antibodies or hypervariable fragments thereof are used.
A number of hypervariable region delineations are in use and are encompassed herein.
Alternatively some genes may contain hypervariable regions.
The extended hypervariable regions are boxed.
Intrinsic antigenic properties of flagellins lacking a hypervariable region.
Hypervariable regions are usually called.
Adjuvant effect of flagellins with hypervariable region deletion.
These hypervariable CDRs are primarily responsible for antigen recognition.
There can be substitutions in both these hypervariable regions.
See also
It was conjectured that the hypervariable regions are involved in antigen binding.
The CDRs are commonly referred to as the hypervariable regions.
Hypervariable control region.
This region is also known as the hypervariable region.
The hypervariable region sequences of the original murine antibodies are boxed.
The SDRs correspond to hypervariable residues.
These hypervariable regions are also called complementarity determining regions or CDRs.
From about two to about fifteen hypervariable region substitutions.
These are the hypervariable regions of immunoglobulin heavy and light chains.
The complementarity determining regions are also called hypervariable domains.
A hypervariable region is a portion of an immunoglobulin that physically binds to the polypeptide target.
We refer to these areas as hypervariable.
Hypervariable codons are indicated by the amino acid position above the bars.
The residues from each of these hypervariable regions are noted below.
Hypervariable regions that were not replaced during the mutagenesis are shown in bold.
It consists essentially of human framework residues and murine hypervariable residues.
These framework and hypervariable sequences may result in undesirable antigenic responses.
So these changes are hypervariable.
The hypervariable or junctional regions are useful for the compositions of the present invention.
The disclosure provides antibodies comprising modifications in these hybrid hypervariable positions.
We find that HpaII restriction sites are hypervariable compared to the other enzymes used.
The region of least sequence homology between flagellins is the hypervariable region.
Computer analysis indicates that all three hypervariable regions are hydrophilic and antigenic.
A synthetic polynucleotide can be employed to vary one or more amino acid in a hypervariable region.
Those hypervariable region residues identified as contributing significantly to antigen binding are candidates for modification.
Single domain antibodies from isolated hypervariable domains can also be used.
These hypervariable loops are directly involved with the interaction of the immunoglobulin with the ligand.
One or more of these positions can also be found in extended hypervariable regions.
This finding indicated that the two hypervariable regions under investigation may be in close contact.
The invention also relates to fusión polypeptides comprising these variant hypervariable regions.
The hypervariable regions as defined by Kabat et al.
The modified antibody may only have a single hypervariable region residue substituted.
CDRs are the hypervariable regions of immunoglobulin heavy and light chains.
Alanine scanning mutagenesis can be performed to identify candidate hypervariable region sites for modification.
There are two mitochondrial hypervariable regions used in human mitochondrial genealogical DNA testing.
