Examples of 'hypervariable region' in a sentence
Meaning of "hypervariable region"
hypervariable region - This phrase is commonly used in genetics and molecular biology to describe a segment of DNA that exhibits significant variation between individuals or species
How to use "hypervariable region" in a sentence
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hypervariable region
The hypervariable region is important for immune recognition.
Adjuvant effect of flagellins with hypervariable region deletion.
A number of hypervariable region delineations are in use and are encompassed herein.
Intrinsic antigenic properties of flagellins lacking a hypervariable region.
The hypervariable region sequences of the original murine antibodies are boxed.
This region is also known as the hypervariable region.
A hypervariable region is a portion of an immunoglobulin that physically binds to the polypeptide target.
From about two to about fifteen hypervariable region substitutions.
A synthetic polynucleotide can be employed to vary one or more amino acid in a hypervariable region.
Those hypervariable region residues identified as contributing significantly to antigen binding are candidates for modification.
The region of least sequence homology between flagellins is the hypervariable region.
Generally, the hypervariable region comes from the mouse.
Alanine scanning mutagenesis can be performed to identify candidate hypervariable region sites for modification.
Each hypervariable region in each library was replaced approximately 50 percent of the time.
The modified antibody may only have a single hypervariable region residue substituted.
See also
Comprises non-human hypervariable region residues and human framework region residues ; or.
Framework or FR residues are those variable domain residues other than the hypervariable region residues.
In contrast, it is known that the hypervariable region is essential for flagellin antigenicity.
Normally, however, the antibody mutant will comprise additional hypervariable region alterations.
Deletion of the hypervariable region impairs the ability to elicit anti-flagellin antibodies.
The last amino acid of the recombinant hypervariable region 4 is a threonine.
In general, the hypervariable region residues are directly and specifically involved in influencing antigen binding.
Any suitable non-human antibody can be used as a source for the hypervariable region.
Each hypervariable region comprises an amino acid sequence corresponding to a complementarity determining region ( CDRs ).
Generally, the antigen-binding residues coincide with the hypervariable region residues of an antibody.
For example, hypervariable region residues can be substituted using the Kunkel method.
In certain embodiments, the modified antibody will only have a single hypervariable region residue substituted.
This so-called hypervariable region I is a major B cell epitope and a target of neutralising antibodies in vivo.
In certain embodiments, the antibody mutant will only have a single hypervariable region residue substituted.
One or more of the hypervariable region residue ( s ) are replaced by alanine or polyalanine residue ( s ).
The antibodies generated against a wild-type flagellin are primarily directed against the hypervariable region.
These results suggest that the central hypervariable region is the major target for anti-flagellin antibodies.
The direct-graft variants were generated by Kunkel mutagenesis using a separate oligonucleotide for each hypervariable region.
The antibody of claim 1 which comprises non-human hypervariable region residues and human framework region residues.
Samples for both sequencing techniques were PCR amplified to target the same V6 hypervariable region.
In another embodiment, a substitution within a hypervariable region sequence is not within an FR.
The hypervariable region comprises amino acid residues from the " complementarity determining regions " or " CDRs ".
The variant has a heavy chain variable domain comprising the following hypervariable region amino acid sequences,.
The hypervariable region comprises amino acid residues from a " complementarity determining region " or " CDR " i . e.
These antibodies are primarily aimed at the hypervariable region ( HPVR ) of the flagellin.
The hypervariable region comprises amino acid residues from a " complementarity determining region " or " CDR ".
No detectable binding was observed with the Mae11 hypervariable region grafted variant.
The hypervariable region generally comprises amino acid residues from a “ complementarity determining region ” or “ CDR ” e . g.
Substitution variants may be generated by substituting one or more hypervariable region residues of Antibody 1.
Hypervariable region 1 ( HVR1 ) and hypervariable region 4 ( HVR4 ) have been identified in the human subgroup C adenoviruses.
Individual fragments for DHPLC ( non multiplex ) of the hypervariable region of the mitochondrial genome.
At the N-terminal end of the coiled-coil rod, there is also a hypervariable region.
Briefly, several hypervariable region sites e . g.
Normally, however, an altered antibody will comprise additional hypervariable region alteration ( s ).
The cloned Apl p44 gene contained a hypervariable region flanked by conserved sequences at the 5 ' and 3 ' ends.
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Examples of using Hypervariable
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Hinge regions are the hypervariable regions of a flagellin
The hypervariable regions are underlined and in bold
Consists of one of the hypervariable regions or loops
Examples of using Region
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The reports from the region were horrifying
The region is constructing buildings to house migrants
An example of such a region is the shelf boundary
