Examples of 'immunoglobulin heavy' in a sentence
Meaning of "immunoglobulin heavy"
immunoglobulin heavy - the larger or main part of an antibody molecule that plays a key role in immune response
How to use "immunoglobulin heavy" in a sentence
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immunoglobulin heavy
Restricted immunoglobulin heavy chain mice.
Alternatively the constant region may not be of immunoglobulin heavy chain origin.
An immunoglobulin heavy chain sequence may be from any organism.
Some modifications at mouse immunoglobulin heavy chain loci are deleterious.
Immunoglobulin heavy chains in the lower panel are indicated by an arrowhead.
Both contained the immunoglobulin heavy chain enhancer IgEnh.
In one aspect the mouse further comprises at least one immunoglobulin heavy chain allele.
The immunoglobulin heavy chains are connected by interchain disulfide bonds.
The human immunoglobulin sequence is an immunoglobulin heavy chain sequence.
The immunoglobulin heavy and light chains are connected by an interchain disulfide bond.
The sequence may comprise a human immunoglobulin heavy chain sequence.
Rearranged mouse immunoglobulin heavy or light chain genes have been used to produce transgenic mice.
These are the hypervariable regions of immunoglobulin heavy and light chains.
Harvesting the immunoglobulin heavy chain variable region and the immunoglobulin light chain variable region.
Therefore with such a nucleic acid only a soluble immunoglobulin heavy chain is obtained.
See also
The immunoglobulin heavy chain constant region is an Fc region.
An antibody has a recognized structure that includes an immunoglobulin heavy and light chain.
Exemplary heterologous immunoglobulin heavy chain sequences include human sequences.
Examples of sequences encoding flexible hinges are found in the immunoglobulin heavy chain hinge region.
Antigen responsivity leads to immunoglobulin heavy chain isotype switching and variable region somatic mutation.
Yet another embodiment is directed to a polynucleotide encoding the disclosed chimeric immunoglobulin heavy chain.
This is the major processing pathway for immunoglobulin heavy chain genes in immunoglobulin secreting cells.
A humanized antibody typically comprises a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain.
Screening for a cell having the immunoglobulin heavy chain polynucleotide sequence randomly integrated in its genome.
Within another related embodiment the second portion is an immunoglobulin heavy chain constant region.
An Fc domain of an immunoglobulin heavy chain is a preferred domain for fusión proteins.
The human VH domain is expressed from an endogenous immunoglobulin heavy chain locus.
The detection of the immunoglobulin heavy chain and light chain is carried out by ELISA.
In some embodiments, the CDRs are from an immunoglobulin heavy chain.
Immunoglobulin heavy and light chain variable regions were amplified using a semi nested PCR approach.
The immunoglobulin constant domain sequence can be an immunoglobulin heavy chain constant domain sequence.
The first and second immunoglobulin heavy chains associate to form the MHC class I molecular complex.
In another embodiment, said immunoglobulin genes comprise immunoglobulin heavy genes.
A domain, of an immunoglobulin heavy chain constant region.
In a specific embodiment, the immunoglobulin protein comprises an immunoglobulin heavy chain.
An antibody comprising the immunoglobulin heavy chain according to claim 0.
In another instance, said immunoglobulin genes comprise immunoglobulin heavy genes.
A method for modifying an immunoglobulin heavy chain locus of a mouse, comprising,.
Figure 4 depicts two allotypes of the mouse immunoglobulin heavy chain.
A CHi domain of an immunoglobulin heavy chain derived from any antibody isotype, e . g.
In one embodiment, the sequence comprises a human immunoglobulin heavy chain sequence.
Preferably, immunoglobulin heavy chain loci endogenous to the mouse are deleted or silenced.
A preferred example of the immunoglobulin heavy chain is Fc.
Immunoglobulin heavy chain runs at 50 kD under reducing conditions and the labeled band is compressed.
CDRs are the hypervariable regions of immunoglobulin heavy and light chains.
As is known, each immunoglobulin heavy chain constant region includes four or five domains.
Homozygous inactivated endogenous immunoglobulin heavy chain loci ; and.
As is known, each immunoglobulin heavy chain constant region comprises four or five domains.
In one embodiment, the second portion is an immunoglobulin heavy chain constant region.
The immunoglobulin heavy chain variable region comprises an amino acid sequence selected from,.
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