Examples of 'immunoglobulin heavy chain' in a sentence
Meaning of "immunoglobulin heavy chain"
immunoglobulin heavy chain - a component of antibodies involved in the immune response
How to use "immunoglobulin heavy chain" in a sentence
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immunoglobulin heavy chain
Restricted immunoglobulin heavy chain mice.
Alternatively the constant region may not be of immunoglobulin heavy chain origin.
An immunoglobulin heavy chain sequence may be from any organism.
Some modifications at mouse immunoglobulin heavy chain loci are deleterious.
Yet another embodiment is directed to a polynucleotide encoding the disclosed chimeric immunoglobulin heavy chain.
Both contained the immunoglobulin heavy chain enhancer IgEnh.
In one aspect the mouse further comprises at least one immunoglobulin heavy chain allele.
Exemplary heterologous immunoglobulin heavy chain sequences include human sequences.
Examples of sequences encoding flexible hinges are found in the immunoglobulin heavy chain hinge region.
Antigen responsivity leads to immunoglobulin heavy chain isotype switching and variable region somatic mutation.
Within another related embodiment the second portion is an immunoglobulin heavy chain constant region.
Screening for a cell having the immunoglobulin heavy chain polynucleotide sequence randomly integrated in its genome.
A humanized antibody typically comprises a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain.
This is the major processing pathway for immunoglobulin heavy chain genes in immunoglobulin secreting cells.
The immunoglobulin heavy chain constant region is an Fc region.
See also
The human immunoglobulin sequence is an immunoglobulin heavy chain sequence.
Harvesting the immunoglobulin heavy chain variable region and the immunoglobulin light chain variable region.
The sequence may comprise a human immunoglobulin heavy chain sequence.
Preferably, immunoglobulin heavy chain loci endogenous to the mouse are deleted or silenced.
Therefore with such a nucleic acid only a soluble immunoglobulin heavy chain is obtained.
An Fc domain of an immunoglobulin heavy chain is a preferred domain for fusión proteins.
The human VH domain is expressed from an endogenous immunoglobulin heavy chain locus.
The detection of the immunoglobulin heavy chain and light chain is carried out by ELISA.
In some embodiments, the CDRs are from an immunoglobulin heavy chain.
A domain, of an immunoglobulin heavy chain constant region.
In a specific embodiment, the immunoglobulin protein comprises an immunoglobulin heavy chain.
An antibody comprising the immunoglobulin heavy chain according to claim 0.
The unrearranged human genomic sequence is present at an endogenous immunoglobulin heavy chain locus ;.
A method for modifying an immunoglobulin heavy chain locus of a mouse, comprising,.
Figure 4 depicts two allotypes of the mouse immunoglobulin heavy chain.
A CHi domain of an immunoglobulin heavy chain derived from any antibody isotype, e . g.
In one embodiment, the sequence comprises a human immunoglobulin heavy chain sequence.
As is known, each immunoglobulin heavy chain constant region includes four or five domains.
The immunoglobulin constant domain sequence can be an immunoglobulin heavy chain constant domain sequence.
As is known, each immunoglobulin heavy chain constant region comprises four or five domains.
Homozygous inactivated endogenous immunoglobulin heavy chain loci ; and.
Immunoglobulin heavy chain runs at 50 kD under reducing conditions and the labeled band is compressed.
A preferred example of the immunoglobulin heavy chain is Fc.
The immunoglobulin heavy chain variable region comprises an amino acid sequence selected from,.
The genetic lesion may be in an immunoglobulin heavy chain J region.
Immunoglobulin heavy chain constant region domains have cross-homology among the immunoglobulin classes.
The polypeptide is an immunoglobulin, an immunoglobulin heavy chain polypeptide, or an immunoglobulin fusion.
The host cell of paragraph 12 wherein the gene product is an immunoglobulin heavy chain.
The polypeptide is an immunoglobulin, an immunoglobulin heavy chain polypeptide, or an immunoglobulin fusión.
A fusión polypeptide as claimed in claim 1, wherein second polypeptide comprises an immunoglobulin heavy chain polypeptide.
In some of these variations, the immunoglobulin heavy chain comprises a variable region.
Immunoreactive bands were visualized by electrochemiluminescence of the immunoglobulin heavy chain ( Ig HC ).
The full-length immunoglobulin heavy chain may comprise the endogenous membrane anchor domain.
In one embodiment, the second portion is an immunoglobulin heavy chain constant region.
VH is an immunoglobulin heavy chain variable domain ;.
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