Examples of 'immunoglobulin locus' in a sentence
Meaning of "immunoglobulin locus"
immunoglobulin locus: a specific location on a chromosome where genes related to immunoglobulins are located. This phrase is commonly used in genetics and immunology
How to use "immunoglobulin locus" in a sentence
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immunoglobulin locus
The immunoglobulin locus is a heavy chain locus.
The chimeric antibody is expressed from an immunoglobulin locus.
The immunoglobulin locus may be a heavy chain locus.
The nucleic acid sequence is at a mouse immunoglobulin locus.
Epigenetic modification of the immunoglobulin locus is central for its transcription and rearrangement.
The nucleic acid sequence may be at a mouse immunoglobulin locus.
Usually, the endogenous immunoglobulin locus of such transgenic mammals is functionally inactivated.
The one or more loci may include an immunoglobulin locus.
In one aspect, a heavy chain immunoglobulin locus is described that comprises a single functional human V segment.
The chimeric antibody may be expressed from an immunoglobulin locus.
In one embodiment, the heavy chain immunoglobulin locus is a modified locus of a non-human animal.
Trangenic mice with a modified endogenous lambda immunoglobulin locus.
In a specific embodiment, the immunoglobulin locus is a heavy chain locus.
Preferably the heavy chain constant region is derived from an immunoglobulin locus.
Alternatively, the transgene is a human immunoglobulin locus or a large portion thereof.
See also
A minilocus light chain transgene may be similarly constructed from the human λ or k immunoglobulin locus.
In certain embodiments, the endogenous immunoglobulin locus is a heavy chain locus.
The modified immunoglobulin sequence may be present at the endogenous mouse heavy chain immunoglobulin locus.
In one embodiment, the genetically modified immunoglobulin locus is present in a germline genome.
Rabbit fibroblasts are transfected with various linearized DNA constructs containing human immunoglobulin locus elements.
In certain other embodiments, the endogenous immunoglobulin locus is a light chain locus.
In various aspects, the non-human animal comprises a human or humanized heavy chain immunoglobulin locus.
In some aspects, the genetically modified immunoglobulin locus is a light chain locus.
In one embodiment, the chimeric antibody is expressed from an immunoglobulin locus.
In some embodiments, the genetically modified immunoglobulin locus is a heavy chain locus.
In one embodiment, the nucleic acid sequence is at a mouse immunoglobulin locus.
Examples of natural gene conversion donors are pseudo-V-genes in the immunoglobulin locus of certain species.
In particular embodiments, the cell comprises an inactivated endogenous immunoglobulin locus.
In a specific aspect, the one or more loci include an immunoglobulin locus.
In one aspect, the nucleic acid sequence is at a mouse immunoglobulin locus.
In a specific embodiment, the one or more loci include an immunoglobulin locus.
In a specific embodiment, the one or more foci include an immunoglobulin locus.
A porcine animal according to claim 1 or claim 2 comprising a xenogenous immunoglobulin locus.
In addition, the mouse cell comprises an inactivated endogenous immunoglobulin locus.
In one aspect, the chimeric antibody is expressed from an immunoglobulin locus.
In one aspect, the cell is homozygous for the modified immunoglobulin locus.
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