Examples of 'immunoglobulin light chain' in a sentence
Meaning of "immunoglobulin light chain"
immunoglobulin light chain: A type of protein molecule in the immune system that is involved in the body's defense against foreign invaders such as bacteria and viruses. There are two types of light chains, kappa and lambda, which combine with heavy chains to form antibodies
How to use "immunoglobulin light chain" in a sentence
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immunoglobulin light chain
An endogenous immunoglobulin light chain k constant region sequence.
Transgenic porcines lacking endogenous immunoglobulin light chain.
Another is the mouse immunoglobulin light chain transcription terminator.
The mouse may further comprise a disabled endogenous immunoglobulin light chain locus.
Immunoglobulin light chain lambda is a marker for immunoglobulin producing cells.
The sequence may comprise a human immunoglobulin light chain sequence.
The immunoglobulin light chain is the small polypeptide subunit of an antibody immunoglobulin.
The expression vector may contain a nucleotide sequence encoding any immunoglobulin light chain.
The immunoglobulin light chain sequence may be an immunoglobulin k light chain sequence.
A humanized antibody typically comprises a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain.
The immunoglobulin light chain precursor ion can be selected using a mass spectrometry technique.
Harvesting the immunoglobulin heavy chain variable region and the immunoglobulin light chain variable region.
The immunoglobulin light chain constant region is a Ck region.
The invention provides a method for detecting immunoglobulin light chain restriction and clonality in B cells.
A human immunoglobulin light chain constant region was derived vÃa amplification of cDNA by a PCR reaction.
See also
In mammals, there are two types of immunoglobulin light chain denoted by λ and k.
Immunoglobulin light chain AL.
In an alternative aspect, the human immunoglobulin light chain is a human λ chain.
Use according to claim 21 wherein said immunoadhesin comprises at least one IgG immunoglobulin light chain.
The kit is for detecting immunoglobulin light chain restriction and clonality in human B cells.
Figure 5 is a schematic depiction of the rabbit immunoglobulin light chain locus.
A humanized immunoglobulin light chain obtainable by a method according to claim 4.
In an alternative embodiment, the human immunoglobulin light chain is a human λ chain.
Selecting an immunoglobulin light chain precursor ion using a mass spectrometry technique ;.
In a specific embodiment, the immunoglobulin protein comprises an immunoglobulin light chain.
In one embodiment, the human immunoglobulin light chain is a human immunoglobulin k chain.
Figure 2 illustrates an example of screening an arrayed human immunoglobulin light chain library.
In one aspect, the mouse immunoglobulin light chain locus is a mouse k locus.
Specifically, the method is practiced in the absence of the immunoglobulin light chain protein.
In a specific embodiment, the immunoglobulin light chain sequence is an immunoglobulin k light chain sequence.
In one embodiment, the sequence comprises a human immunoglobulin light chain sequence.
In one aspect, the immunoglobulin light chain constant region gene sequence is a mouse sequence.
In one aspect, the human immunoglobulin sequence is an immunoglobulin light chain sequence.
In some embodiments, the human immunoglobulin light chain variable domain is a k light chain variable domain.
In particular embodiments, the genome further comprises a non-endogenous immunoglobulin light chain.
The sc-TCR is further linked to an immunoglobulin light chain produced the hybridoma cell.
The cell according to claim 1, further comprising a second synthetic transgene encoding a human immunoglobulin light chain.
Optionally, the constant domain of an immunoglobulin light chain can be of the λ type.
In certain embodiments, the genome of the disclosed cell further comprises a non-endogenous immunoglobulin light chain.
In some certain aspects, the endogenous immunoglobulin light chain locus is a k light chain locus.
The expression vector of the present invention may contain a nucleotide sequence encoding a G250 immunoglobulin light chain.
In one aspect, the first and / or the second immunoglobulin light chain domain is from a rodent.
Said immunoglobulin light chain may be identical to the sequence of SEQ ID NO, 2.
In one embodiment, the mouse further comprises a disabled endogenous immunoglobulin light chain locus.
In one embodiment, the mouse expresses an immunoglobulin light chain that comprises a mouse constant sequence.
The illustrated AFRA light chain has a structure which is typical of an immunoglobulin light chain ( L ).
In one aspect, the second immunoglobulin light chain constant region is from a non-human animal.
In one aspect, the non-human animal lacks a functional unrearranged immunoglobulin light chain variable region.
VI is an immunoglobulin light chain variable domain ;.
References to " VL " refer to the variable region of an immunoglobulin light chain.
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