Examples of 'modified internucleoside' in a sentence
Meaning of "modified internucleoside"
modified internucleoside: Refers to a type of molecule or compound that has been altered or adjusted at the internucleoside level, commonly used in biochemistry or molecular biology
How to use "modified internucleoside" in a sentence
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modified internucleoside
In one embodiment the modified internucleoside linkage is phosphorothioate.
The modified oligonucleotide may comprise at least one modified internucleoside linkage.
The modified internucleoside linkage may comprise a phosphorothioate linkage.
A phosphorothioate linkage is a modified internucleoside linkage.
Other modified internucleoside linkages include at least one phosphorothioate linkage.
The antisense oligonucleotide of any preceding claim having at least one modified internucleoside linkage.
A preferred phosphorus containing modified internucleoside linkage is the phosphorothioate internucleoside linkage.
The phosphoramidite approach has been used to synthesize oligonucleotides having a variety of modified internucleoside linkages.
One or more modified internucleoside linkages ;.
Included among such oligonucleotides are chimeric oligonucleotides having different types of modified internucleoside linkages.
In certain embodiments, a modified internucleoside linkage comprises a phosphorus atom.
Antisense compounds targeted to a huntingtin nucleic acid comprise one or more modified internucleoside linkages.
In certain instances, the modified internucleoside linkages are phosphorothioate linkages.
In one embodiment the ORN further comprises at least one modified internucleoside linkage.
In certain embodiments, the modified internucleoside linkages are phosphorothioate linkages.
See also
In certain instances, antisense oligonucleotides have at least 3 modified internucleoside linkages.
In some embodiments, the modified internucleoside linkages are phosphorothioate linkages.
For example, a phosphorothioate linkage is a modified internucleoside linkage.
In certain embodiments, each modified internucleoside linkage is a phosphorothioate internucleoside linkage.
In certain embodiments, oligonucleotides comprise a region of uniformly modified internucleoside linkages.
In certain embodiments, such modified internucleoside linkage is a phosphorothioate internucleoside linkage.
In certain embodiments, antisense oligonucleotides have at least 3 modified internucleoside linkages.
In certain embodiments, the modified internucleoside linkage is a phosphorothioate internucleoside linkage.
In certain embodiments, at least one internucleoside linkage is a modified internucleoside linkage.
In certain embodiments, the modified internucleoside linkages are interspersed throughout the antisense compound.
A nucleic acid can comprise a modified backbone and / or modified internucleoside linkages.
Yet again in the same aspect, the modified internucleoside linkage can be a phosphorothioate internucleoside linkage.
In certain embodiments, antisense oligonucleotides have at least one modified internucleoside linkage.
The antisense oligonucleotide of claim 1 having at least one modified internucleoside linkage or nucleobase.
In certain embodiments, the modified oligonucleotide has at least one modified internucleoside linkage.
A phosphorothioate linkage ( P = S ) is a modified internucleoside linkage.
In certain embodiments, oligonucleotides of the present disclosure comprise a region of uniformly modified internucleoside linkages.
In certain embodiments, the compound has at least one modified internucleoside linkage.
The oligonucleotide of any preceding claim, comprising at least one modified internucleoside linkage.
In certain embodiments, the modified oligonucleotide comprises at least one modified internucleoside linkage.
In certain embodiments, the antisense compound comprises at least one modified internucleoside linkage.
In the same aspect, the modified oligonucleotide can comprise at least one modified internucleoside linkage.
A nucleic acid-targeting nucleic acid can comprise a modified backbone and / or modified internucleoside linkages.
In some embodiments, a PDGF aptamer comprises at least one modified internucleoside linkage.
In some embodiments, a VEGF aptamer comprises at least one modified internucleoside linkage.
In certain embodiments, siRNA compounds may comprise unmodified RNA nucleosides, but modified internucleoside linkages.
The single-stranded oligodeoxyribonucleotide of claim 17, comprising two or more modified internucleoside phosphate linkages.
The 3 ′ 3 ′ - linkage may be a phosphodiester, phosphorothioate or any other modified internucleoside bridge.
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Examples of using Internucleoside
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Each internucleoside linkage is a phosphorothioate internucleoside linkage
In one embodiment the modified internucleoside linkage is phosphorothioate
The internucleoside linkages of each compound are phosphorothioate throughout
