Examples of 'internucleoside' in a sentence
Meaning of "internucleoside"
internucleoside (noun): A compound formed between two nucleosides
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- Between nucleosides
How to use "internucleoside" in a sentence
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internucleoside
Each internucleoside linkage is a phosphorothioate internucleoside linkage.
In one embodiment the modified internucleoside linkage is phosphorothioate.
The internucleoside linkages of each compound are phosphorothioate throughout.
The modifications typically concern a nucleoside or internucleoside link.
The internucleoside linkages are phosphorothioate linkages.
A phosphorothioate linkage is a modified internucleoside linkage.
The internucleoside linkage may be a phosphorothioate internucleoside linkage.
Subscript s represents a phosphorothioate internucleoside linkages.
The modified internucleoside linkage may comprise a phosphorothioate linkage.
The oligonucleotide analog can have any type of internucleoside linkage.
Certain types of carbamate internucleoside linkages are known in the art.
Internucleoside linkage may be used interchangeably with internucleotide linkage.
In all the following oligonucleotides the internucleoside linkage is a phosphorothioate linkage.
The internucleoside linkages constitute the backbone of a nucleic acid molecule.
A preferred phosphorus containing modified internucleoside linkage is the phosphorothioate internucleoside linkage.
All internucleoside linkages are phosphorothioate internucleoside linkages unless otherwise indicated.
Oligonucleotides containing phosphorothioate internucleoside linkages have been shown to be more stable in vivo.
Internucleoside linkages are phosphorothioate.
The first and second ester bond represent the internucleoside linkage.
Other modified internucleoside linkages include at least one phosphorothioate linkage.
The modified oligonucleotide may comprise at least one modified internucleoside linkage.
The phosphite internucleoside linkage is then oxidized using a suitable oxidizing agent.
The first type includes modifications to the normal internucleoside phosphodiester linkage.
In another embodiment each internucleoside linkage of the antisense oligonucleotide is a phosphorothioate internucleoside linkage.
The covalent linkage between two nucleosides may be referred to as an internucleoside linkage.
The internucleoside linkage may be the natural occurring phospodiester linkage or a derivative thereof.
The phosphate groups are commonly referred to as forming the internucleoside backbone of the oligonucleotide.
The internucleoside linkage can be the natural occurring phospodiester linkage or a derivative thereof.
The antisense oligonucleotide of any preceding claim having at least one modified internucleoside linkage.
In certain embodiments, each internucleoside linking group is a phosphorothioate.
The phosphoramidite approach has been used to synthesize oligonucleotides having a variety of modified internucleoside linkages.
One or more modified internucleoside linkages ;.
Included among such oligonucleotides are chimeric oligonucleotides having different types of modified internucleoside linkages.
In certain embodiments, a modified internucleoside linkage comprises a phosphorus atom.
Antisense compounds targeted to a huntingtin nucleic acid comprise one or more modified internucleoside linkages.
In certain embodiments, each internucleoside linkage is a phosphorothioate internucleoside linkage.
The left hand structure below shows the phosphate group found in natural internucleoside backbone linkages.
In certain instances, the modified internucleoside linkages are phosphorothioate linkages.
An S following a nucleotide denotes a backbone modification consisting of a phosphorothioate internucleoside linkage.
In certain embodiments, the internucleoside linkage is a phosphorothioate internucleoside linkage.
In one embodiment the ORN further comprises at least one modified internucleoside linkage.
The internucleoside ( backbone ) linkages are phosphorothioate throughout the oligonucleotide.
A further preferred nucleotide analogue of the invention is wherein the internucleoside phosphate linkage is a phosphorothioate.
In some embodiments, each internucleoside linkage is a phosphorothioate internucleoside linkage.
Usually, the mononucleotides are linked through an internucleoside linkage.
The internucleoside ( backbone ) linkages are phosphodiester throughout the oligonucleotide.
For example, a phosphorothioate linkage is a modified internucleoside linkage.
In certain instances, each internucleoside linkage is a phosphorothioate internucleoside linkage.
In certain instances, antisense oligonucleotides have at least 3 modified internucleoside linkages.
In certain embodiments, the modified internucleoside linkages are phosphorothioate linkages.
