Examples of 'nucleotide analog' in a sentence
Meaning of "nucleotide analog"
Nucleotide analog: This scientific term refers to a compound that is structurally similar to a nucleotide and can be incorporated into DNA or RNA during replication or transcription. Nucleotide analogs are often used in research or as antiviral or anticancer drugs to disrupt nucleic acid synthesis
How to use "nucleotide analog" in a sentence
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nucleotide analog
A nucleotide can comprise a synthetic nucleotide analog.
In some embodiments the nucleotide analog comprises a reversible terminator.
A is the residue of a phosphonomethoxy nucleotide analog.
Cidofovir is a nucleotide analog that is active against most all human herpesviruses and poxviruses.
This medication is a nucleotide analog.
In another embodiment the nucleotide analog is a natural nucleotide having a chemical modification that is removable.
Nucleotide may be any natural or unnatural nucleotide or any nucleotide analog.
AraC is a nucleotide analog that is toxic to dividing cells.
The medicaments of the invention further may comprise a nucleotide analog.
At least one nucleotide analog can be incorporated into the DNA.
The returned light spectrum identifies the particular bound nucleotide analog.
The first being reduced incorporation of the nucleotide analog into DNA over the normal nucleotide.
In another embodiment the palindromic regions include at least one nucleotide analog.
This is most efficiently achieved by giving each nucleotide analog a different distinguishable label.
In some embodiments an adaptor comprises a functional moiety for chemical ligation to a nucleotide analog.
See also
In some embodiments, a nucleotide analog is an unnatural nucleotide.
The nucleotide monomer units may comprise any nucleotide or nucleotide analog.
Nucleotide analog reverse-transcriptase inhibitor.
Related embodiments provide compositions that comprise a nucleotide analog and a polymerase.
In some instances, the nucleotide analog comprises a reversible terminator.
At least one of the helper oligonucleotides can include at least one nucleotide analog.
In some embodiments, the nucleotide analog is as described in other sections herein.
The radiolabel used for each assay matched the class of nucleotide analog screened.
In other embodiments, the labeled nucleotide analog is a radioactively labeled nucleotide.
The method for detecting the RNA is selected based on the labeled nucleotide analog employed.
Alternatively, siRNA sequences with nucleotide analog substitutions or insertions can be effective for inhibition.
In another embodiment, the polynucleotide can include at least one nucleotide analog.
In one embodiment, the antiviral agent is a nucleotide analog reverse transcriptase inhibitor.
Disclosed herein are several antimetabolite anti-cancer agents which may be is a nucleotide or a nucleotide analog.
In some embodiments the non-base pairing nucleotide analog is a ribonucleotide.
Nucleotide analog substitutions do not protect the primer strand from all restriction endonucleases, however.
In other embodiments the non-base pairing nucleotide analog is a deoxyribonucleotide.
Disclosed herein but not claimed, the antimetabolite anti-cancer agent is a nucleotide or a nucleotide analog.
Alternatively, DsiRNA agent sequences with nucleotide analog substitutions or insertions can be effective for inhibition.
The term " probe " denotes a defined nucleic acid segment or nucleotide analog segment.
Sofosbuvir is a nucleotide analog NS5B polymerase inhibitor developed by Gilead Sciences, Inc.
The oligonucleotide probe of claim 1, wherein said oligonucleotide probe comprises at least one nucleotide analog.
Preferably, the nucleotide analog has a methoxy group at the 2 ' position of a ribose moiety.
Additionally, a moiety may be linked to the oligonucleotide through a nucleotide analog incorporated into the oligonucleotide.
For example, a nucleotide analog can have a modified base, either naturally existing or man-made.
The use of claim 1, wherein said antiproliferative agent is a nucleotide analog.
AD is a nucleotide analog having antiviral activity against HIV, HBV, CMV, and several other viruses.
In some embodiments, determining the n nucleotide subsequences comprises terminating polymerization with a 3 ′ - O-blocked nucleotide analog.
In one embodiment the nucleotide analog has a 3 ' - hydroxyl group.
A nucleotide analog may be a naturally occurring nucleotide ( e.g., inosine ) or a non-naturally occurring nucleotide.
The use of claim 11, wherein said nucleotide analog is a 6-mercaptopurine drug.
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