Examples of 'phosphodiester' in a sentence
Meaning of "phosphodiester"
phosphodiester (noun): A chemical compound containing a phosphorus atom connected to two oxygen atoms and another atom or group
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- any of many biologically active compounds in which two alcohols form ester bonds with phosphate
- any phospholipid, such as lecithin, that has two ester groups
How to use "phosphodiester" in a sentence
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phosphodiester
All phosphodiester groups are replaced methylphosphonate groups.
This may derive from deoxyribose phosphodiester.
All phosphodiester groups are replaced by phosphorothioate groups.
Each incorporated nucleotide contains an activated phosphodiester.
Saccharides comprising phosphodiester bonds are unstable to hydrolysis.
Phophorothioate is used to modify the phosphodiester linkage.
Any phosphodiester can be substituted by a phosphorothiodiester or methyphosphonodiester.
The linkage is preferably a nucleotide phosphodiester linkage.
There is no phosphodiester bond at each end of the polynucleotide.
All oligomer sequences are unmodified phosphodiester oligodeoxynucleotides.
Synthetic phosphodiester oligonucleotides and therapeutical uses thereof.
The backbones of the sequences are phosphodiester backbones.
The first phosphodiester bond is formed.
Usually nucleosidic monomers are linked by phosphodiester bonds.
All or part of the phosphodiester bonds are advantageously protected.
See also
All oligodeoxynucleotides were purchased as unmodified phosphodiester oligodeoxynucleotides.
Phosphodiester bonds are attacked by a variety of nucleases.
Saccharides comprising phosphodiester bonds may be unstable to hydrolysis.
The liaison between two nucleosides is a phosphodiester liaison.
By phosphodiester bonds through the.
A linkage fragment can also be a phosphodiester or phosphodiester modification.
In one embodiment the nucleobase linkages are all phosphodiester.
The phosphate groups in the phosphodiester bond are negatively charged.
Each strand is a chain of nucleosides linked by phosphodiester bonds.
Phosphodiester internucleotide linkages are afforded by oxidation with aqueous iodine.
Nucleases can hydrolyze nucleic acid phosphodiester bonds.
Phosphodiester internucleotide linkages were afforded by oxidation with aqueous iodine.
In some embodiments the linkages include phosphodiester bonds.
The phosphodiester analogues are more resistant to attack by cellular nucleases.
Non furanose sugar units with a phosphodiester linkage.
One or more phosphodiester linkages may be replaced by alternative linking groups.
These terms encompass nucleotides connected by phosphodiester linkages.
The two stem regions by a phosphodiester linkage or modified phosphodiester linkage.
In some embodiments the compound comprises a phosphodiester bond.
One or more phosphodiester linkages can be replaced by alternative linking groups.
The uppercase letters are nucleotides with phosphodiester backbone.
Oligonucleotides containing phosphodiester or modified linkages can be synthesized by standard techniques.
The line between the nucleosides represents a phosphodiester bond.
The usefulness of such phosphodiester compounds in medical applications is well known.
In various embodiments all the covalent bonds are phosphodiester bonds.
Both phosphorothioate and phosphodiester nucleic acids are active in immune cells.
Preferably the guanine and thymine bases are phosphodiester bases.
Ascorbic cholesteryl phosphodiester acid was prepared utilizing the following procedure.
Thus the linkage between two nucleotides is called a phosphodiester bond.
Part of the phosphodiester groups in its internucleotide skeleton is replaced by phosphorothioate groups.
Early synthetic approaches included phosphodiester and phosphotriester chemistries.
In another embodiment the mixed duplex oligonucleotide is linked by unsubstituted phosphodiester bonds.
Ligation refers to creation of a phosphodiester bond between two residues.
Phosphorothioate samples typically contained less than one percent of phosphodiester linkages.
Characterization of phosphodiester adducts produced by the reaction of cyanoethylene oxide with nucleotides.
