Examples of 'phosphodiester linkages' in a sentence
Meaning of "phosphodiester linkages"
phosphodiester linkages: Chemical bonds that connect the sugar-phosphate backbones in nucleic acids like DNA and RNA
How to use "phosphodiester linkages" in a sentence
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phosphodiester linkages
These terms encompass nucleotides connected by phosphodiester linkages.
One or more phosphodiester linkages may be replaced by alternative linking groups.
Nucleosides that are linked by unsubstituted phosphodiester linkages are termed nucleotides.
One or more phosphodiester linkages can be replaced by alternative linking groups.
Phosphorothioate samples typically contained less than one percent of phosphodiester linkages.
The internal phosphodiester linkages of the natural cGAMP produced by cGAS remain to be determined.
In certain examples, the linkages are all phosphodiester linkages.
None of these compounds having solely phosphodiester linkages exhibit either endonuclease or exonuclease resistance.
In certain embodiments, the linkages are all phosphodiester linkages.
Oligomers can contain conventional phosphodiester linkages or can contain phosphodiester modification such as phosphoramidate linkages.
Polynucleotide " means a sequence of nucleotides connected by phosphodiester linkages.
The compounds with selected internucleotide phosphodiester linkages have antiviral activity and increased metabolic stability.
While modified linkages are useful, the ONs can include phosphodiester linkages.
As noted above, one or more phosphodiester linkages may be replaced by alternative linking groups.
In some embodiments, one or more linkages between the nucleotides are phosphodiester linkages.
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As noted above, one or more phosphodiester linkages can be replaced by alternative linking groups.
Accordingly, its backbone is not necessarily limited to the one vía phosphodiester linkages.
Analogs of phosphodiester linkages notably include phosphorothioate, phosphorodithioate, phosphoramidate and the like.
In some embodiments, a modified polynucleotide oligomer comprises one or more phosphodiester linkages.
Modified phosphodiester linkages that have been reported to date are phosphorothioates, alkylphosphotriesters, methylphosphonates and alkylphosphoramidates.
The term “ polynucleotide ” as used herein means a sequence of nucleotides connected by phosphodiester linkages.
Fig . 4 displays the family of altered phosphodiester linkages compatible with colinear triplex formation.
Thus, oligonucleotide probes may have constituent bases joined by peptide bonds rather than phosphodiester linkages.
Analogs of phosphodiester linkages include phosphorothioate, phosphorodithioate, phosphoranilidate, phosphoramidate, and the like.
After completion of the sequence all H-phosphonate bonds are simultaneously oxidized to phosphodiester linkages.
Analogs of phosphodiester linkages include phosphorothioate, phosphorodithioate, phosphoroselenoate, phosphorodiselenoate, phosphoroanilothioate, phosphoranilidate, phosphoramidate, and the like.
The diagonal lines with ' P ' in a circle refer to the phosphodiester linkages linking each ribose.
Analogs of phosphodiester linkages include phosphothioate, phosphodithioate, phosphoselenate, phosphodiselenate, phosphoroanilothioate, phosphoranilidate, phosphooramidite, and the like.
Nucleic acids are generally a polymer of nucleotides joined by 3 ' 5 ' phosphodiester linkages.
Methylation of phosphodiester linkages to produce P ( O ) - methyl derivatives has been reported.
Usually, nucleoside monomers of a " polynucleotide oligomer " are linked by phosphodiester linkages.
The non-stabilized linkages are preferably natural linkages, i.e., phosphodiester linkages or phosphodiester-like linkages.
In some embodiments it is preferred that the oligonucleotides include 3-6 phosphodiester linkages.
I have isolated 247 base-paired linear polymer nucleotides stranded by phosphodiester linkages at position five.
Preferred polynucleotides are those in which the various subunits are linked by internucleotide 5 ' -3 ' phosphodiester linkages.
I have isolated 247 base paired linear polymer nucleotides stranded by phosphodiester linkages at position five.
Nucleotides of the immunostimulatory ORN of the invention can also be joined through 3 ′ -5 ′ phosphodiester linkages.
Compound c has three DNA / RNA ( such as DNA ) nucleosides linked by a phosphodiester linkages.
RNA is a polymer of ribonucleotides joined through 3 ′ -5 ′ phosphodiester linkages.
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Examples of using Phosphodiester
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All phosphodiester groups are replaced methylphosphonate groups
This may derive from deoxyribose phosphodiester
All phosphodiester groups are replaced by phosphorothioate groups
Examples of using Linkages
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