Examples of 'replication competent' in a sentence
Meaning of "replication competent"
replication competent: This term is often used in scientific research to describe a substance or organism that is capable of reproducing or duplicating itself accurately
How to use "replication competent" in a sentence
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replication competent
In one embodiment the adenovirus is replication competent.
Producer cells for replication competent retroviral vectors.
Such a recombinant molecule preferably is replication competent.
Retroviral vectors may be replication competent or replication defective.
The adenoviral vector of the invention can be replication competent.
Retroviral vectors can be replication competent or replication defective.
Replication competent viruses capable of silencing virus inhibitory factor expression.
The present invention produces a replication competent polynucleotide.
The replication competent polynucleotide of the invention can be present in a vector.
In certain aspects the rISFV is a replication competent virus.
The absence of replication competent virus was verified by mobilization assay.
The infectious agent may be a replication competent poxvirus.
The replication competent polynucleotides may further include a second coding sequence.
The present invention relates only to replication competent virus.
It is possible to use replication competent or replication deficient viral vectors.
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The retroviral vector may be incapable of replication or it may be replication competent.
In one embodiment the replication competent oncolytic virus is a chimeric virus.
These factors are provided by the genome of the replication competent virus.
A new generation of replication competent oncolytic adenoviruses is currently in the clinic.
The retroviral vectors of this invention are replication competent in avian cells.
The presence of replication competent virus was excluded by HeLa cell assays.
None of the virus used in the following procedures was replication competent.
Viral vectors may be either replication competent or replication defective retroviral vectors.
Replication competent viruses are preferred for the use of the present invention.
Said formulations preferably consist of said replication competent adenovirus and a diluent.
These replication competent adenoviral vectors are well known by the one skilled in the art.
A variation involves the use of replication competent virus in place of helper cells.
Said replication competent adenoviruses have a host range that allows replication in said cells.
This limits the duration of in vivo replication of an administered replication competent adenovirus.
In some aspects of the invention a replication competent polynucleotide includes a second coding region.
Also provided by the present invention are methods for selecting a replication competent polynucleotide.
Host cells transfected with a replication competent retroviral vector of the disclosure are provided.
Retroviral vector systems are optimized to minimize the chance of replication competent virus being present.
A variant replication competent polynucleotide may have a faster replication rate than the parent or input polynucleotide.
A viral particle that is both infectious and replication competent may be referred to as a virion.
The replication competent TGEV vector may be infectious or not.
The subject is contacted with a recombinant replication competent retroviral vector of the disclosure.
The replication competent retroviral vector can comprise an Orthoretrovirus or more typically a gamma retrovirus vector.
The subject is contacted with a recombinant replication competent retroviral vector of the present invention.
Replication competent hepatitis C virus and methods of use.
The present invention provides recombinant replication competent retroviral vectors for gene delivery.
A preferred method of transfecting a cell with an HCV polynucleotide is with replication competent RNA.
The presence of a cell that replicates indicates the replication competent polynucleotide produces infectious virus particles.
The replication competent TGEV sequences need not but may further encode other TGEV proteins.
Herein is disclosed a method for identifying a compound that inhibits replication of a replication competent polynucleotide.
This vector can be replication competent Logg et al.
Alternatively, the viral vectors may be conditionally replicating or replication competent.
This vector can be replication competent CR.
Even so, replication competent retroviruses do occur at a low frequency.
The method includes incubating a cell that contains a replication competent polynucleotide of the present invention.
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