Examples of 'replication defective' in a sentence
Meaning of "replication defective"
replication defective: referring to a situation where the process of replication (copying or reproducing something) is flawed or faulty
How to use "replication defective" in a sentence
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replication defective
The adenovirus vector is typically replication defective.
Preparation of replication defective influenza virus.
Retroviral vectors may be replication competent or replication defective.
A replication defective virus is a virus defective for a constitutive protein.
The adenovirus of the invention may be replication defective.
Replication defective virus.
Retroviral vectors can be replication competent or replication defective.
Replication defective viruses.
The adenovirus may be replication defective.
Use replication defective adenoviruses to deliver physiological levels of recombinant protein to systemic circulation.
The resulting virus is replication defective.
Replication defective viruses harboring a partially or completely destroyed integrase can be constructed several different ways,.
The adenovirus vectors of the invention are typically replication defective.
Construction of useful replication defective retroviral vectors is a matter of routine skill.
The viral vectors used in the methods can be replication defective.
See also
These viral particles are replication defective but can infect a wide range of mammalian cells.
Live vectors for use in the invention may be replication defective.
The lentiviral vectors are replication defective and do not contain the genes required for replication.
It is preferable that the recombinant viral vector is a replication defective recombinant virus.
Viral protein El deleted replication defective adenoviruses are routinely employed in gene therapy protocols.
The adenovirus vectors useful in the present disclosure are typically replication defective.
May lentiviruses have already been split into replication defective genomes and packaging components.
The adenovirus vector according to any preceding claim wherein the virus is replication defective.
Many retroviruses have already been split into replication defective genomes and packaging components.
More preferably, all of the deletions are deletions that would render the adenovirus replication defective.
Compositions comprising the replication defective CMV are also encompassed by the present invention.
Thus codon optimisation is a novel method of obtaining a replication defective viral particle.
The virus will be replication defective when the E1 locus has been deleted.
Viral vectors may be either replication competent or replication defective retroviral vectors.
Retroviruses, replication defective retroviruses, adenoviruses, replication defective adenoviruses, and adeno-associated viruses.
The term as used herein also includes viruses that are replication defective.
A method to prepare infectious replication defective influenza virus, comprising,.
Viral propagation generally will occur only in complementing host cells comprising replication defective vectors.
Of course, the effectiveness of the replication defective hepatitis viruses is dose related.
For use in human patients, the retroviral vectors must be replication defective.
Similarly, mixtures of different replication defective viruses can be employed in the same composition.
In a preferred embodiment the adenovirus used as a live vector is a replication defective simian adenovirus.
The Alpha virus vector system is replication defective due to deletion / replacement of structural genes.
In various embodiments, the retrovirus is replication defective.
A composition comprising the conditional replication defective CMV of any of claims 1-8 and a pharmaceutically acceptable carrier.
In some embodiments, the adenovirus vector is replication defective.
A first DNA sequence encoding a replication defective retroviral vector, which comprises.
For use in cells in human patients, the retroviral vectors must be replication defective.
A vertebrate cell, transfected by the recombinant, replication defective virus of the invention is also provided.
The method of any one of claims 1 to 13, wherein the retrovirus is replication defective.
The adenovirus vectors may be replication defective adenovirus comprising a functional E1 deletion.
The invention also provides a method to prepare infectious replication defective influenza virus.
The adenovirus vectors were replication defective due to deletions in the E1 and E3 region.
Suitably, the viral vector is an adenovirus vector, preferably a replication defective adenovirus vector.
A composition comprising the conditional replication defective CMV of any of embodiments 1-14 and a pharmaceutically acceptable carrier.
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