Examples of 'replication deficient' in a sentence
Meaning of "replication deficient"
replication deficient: This phrase describes a state where something lacks the ability to replicate or reproduce, often used in scientific contexts
How to use "replication deficient" in a sentence
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replication deficient
The adenoviruses used may be replication deficient.
Replication deficient adenovirus is an efficient vehicle for liverdirected gene delivery.
Preferably the simian adenoviral vector is replication deficient.
The viral vector may be a replication deficient or conditionally replication deficient viral vector.
The viruses used in the invention are preferably replication deficient.
An arenavirus particle may be rendered replication deficient by genetic modification of its genome.
The adenovirus vectors useful in the invention are typically replication deficient.
Replication deficient retroviral vectors lack certain genes required for successful reproduction of the virus.
Said recombinant adenovirus is not a replication deficient adenovirus.
A recombinant replication deficient virus for use according to claim 1 which is an adenovirus or a papillomavirus.
It is possible to use replication competent or replication deficient viral vectors.
Generally, a replication deficient adenovirus would be administered alone or in admixture with an immunosuppressive agent.
In some preferred aspects, viral vectors are replication deficient.
In particular, replication deficient retroviral vector particles can be produced in accordance with the disclosure.
Preferably, the influenza virus is a replication deficient virus.
See also
The helper independent replication deficient human adenovirus 5 system is used to prepare transgene containing vectors.
Preferably, the adenoviruses used in the present invention are replication deficient.
Preferred is the helper-independent replication deficient human adenovirus system.
Hence, some replication deficient viral mutants may preferentially exhibit a replication phenotype in neoplastic cells.
Even more preferably, said retrovirus or lentivirus is a replication deficient virus.
Such replication deficient viruses may also have crippling modifications in the packaging / enhancer domain.
Specifically, the influenza virus of the invention is a replication deficient virus.
The method of claim 1 wherein the replication deficient ALV vector is contained in a plasmid.
The use of claim 3, wherein the adenoviral vector is replication deficient.
The adenovirus was made replication deficient by deleting the E1 region.
Sf21 cells were co-transfected with pBacHISMgD and replication deficient virus.
Such replication deficient adenovirus species are referred to as E1a-RB ( - ) replication deficient adenoviruses.
In the preferred practice of the invention, the vectors are replication deficient or conditionally replicating.
Preparation of recombinant replication deficient adenoviruses . Several recombinant replication deficient adenoviruses ( type 5 ) were constructed.
A method according to claim 76, wherein the retrovirus is a replication deficient recombinant retroviral vector.
Representative replication deficient transfection viruses include the adenovirus Ad2-CMV-LacZ-2.
The nucleic acid sequence of claim 14, wherein the adenoviral vector is replication deficient.
The nucleic acid construct of claim 8 or 9, comprising a replication deficient adenovirus ( type 5 ) expression vector.
Such contacting results in infection of the cell population with the E1a-RB ( - ) replication deficient adenovirus.
Sf21 insect cells were co-transfected with pBacHISgD, LH and replication deficient baculovirus viral DNA.
The Ad-rSPD adenovirus has deletions in E1 and E3 regions and is replication deficient.
The method of any of claims 1-8, wherein the adenoviral vectors are replication deficient adenoviral vectors.
Deletion of the PB1-F2 increases efficacy of the intranasal replication deficient vaccine.
Deletion of E1A and E1B region renders the virus replication deficient in vivo.
Such contacting results in infection of the cell population with the E1b-p53 ( - ) replication deficient adenovirus.
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