Examples of 'serum half-life' in a sentence
Meaning of "serum half-life"
serum half-life"}, {"a": "In the medical field, 'serum half-life' refers to the time it takes for half of a drug or substance to be eliminated from the bloodstream. This measurement helps determine the frequency and dosage of medication.
How to use "serum half-life" in a sentence
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serum half-life
Enhances the serum half-life of said polypeptide.
Several variants have been assessed for serum half-life in rats.
Assessments of the serum half-life and immunogenicity of proteins and peptides e . g.
Both fusión proteins had a similar serum half-life in mice.
The in vivo serum half-life of all of the formats was also determined in mice.
Hemodialysis does not alter this serum half-life of doxycycline.
Preparations having a higher sialic acid content generally exhibited prolonged serum half-life.
Modifications that can enhance serum half-life are of interest.
An additional reliable indicator of possible hepatic injury is the serum half-life.
It can be estimated by the serum half-life of the labeled annexin.
The chimeric polypeptide may have an increased serum half-life.
A method for increasing the serum half-life of a therapeutic active protein comprising,.
In certain embodiments, the chimeric polypeptide has an increased serum half-life.
By way of further example, serum half-life may be measured in a human or animal model.
Another important advantage of chimeric monoclonals is the increased serum half-life.
See also
Conversely, a longer serum half-life may be desirable for recruiting effector functions.
Amiloride has been estimated to have a serum half-life of about six hours.
In other embodiments, the soluble cytokine receptor is pegylated to increase its serum half-life.
In patients with reduced renal function, the serum half-life of cefaclor is slightly prolonged.
Correlation of the serum concentration with time allows calculation of the serum half-life.
The role of FcRn affinity in affecting serum half-life has particular promise for medicine.
Extended serum half-life may allow a lower or less frequent dosing regimen of the mutein.
It is also often useful to alter the serum half-life of the antibody.
The increase in serum half-life was comparable to that seen for the IgG-YTE variant.
Various adzyme characteristics that can extend or decrease serum half-life are described above.
The FSH serum half-life can be increased by further modifying the superactive FSH.
Such an amino acid substitution can dramatically reduce the serum half-life of an antibody.
However, its serum half-life is relatively short.
For intravascular administration, the particle size determines serum half-life and destination.
The serum half-life after either intramuscular or intravenous administration is approximately 70 minutes.
Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5.
For example, the sialic acid moiety of a protein plays a major role in serum half-life.
Selecting a mutation that increases the serum half-life of the antibody-based fusión protein.
The chimeric polypeptide may have both increased affinity for FcRn and increased serum half-life.
An Fc may also increase the serum half-life of an antibody.
CNP variants of the disclosure advantageously retain CNP activity and exhibit increased serum half-life.
The Fc variant protein may have enhanced serum half-life relative to comparable molecule.
In one embodiment, the antibody is altered to improve its serum half-life.
Regarding activity and / or serum half-life of the protein.
PEG increases the molecular weight and hence the serum half-life.
The serum half-life of a polypeptide can be determined, for example, by pharmacokinetic analysis.
A model has been proposed for how FcRn might regulate the serum half-life of an antibody.
Elevated serum half-life can be maintained by the use of sustained-release protein " packaging " systems.
Injection of the protein the peak values are lower but the serum half-life is prolonged.
Elevated serum half-life can be maintained by the use of sustained-release polypeptide " packaging " systems.
In one embodiment, the Fc variant protein has enhanced serum half-life relative to comparable molecule.
Accordingly, the larger the hydrodynamic size of the PEGylated molecule, the greater the serum half-life.
In this respect, the advantageously long serum half-life of the anti-EpCAM immunoglobulin is exploited.
In one case, the antibody is altered to improve its serum half-life.
Table 1, Serum half-life estimates in humans and experimental animals.
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Examples of using Half-life
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The half-life was prolonged in these patients
There is no change in half-life during treatment
Each elimination phase determines a half-life
