Examples of 'vivo half-life' in a sentence
Meaning of "vivo half-life"
vivo half-life - This phrase can be a misunderstanding or misinterpretation. It could be a combination of 'vivo', which means relating to a living organism, and 'half-life', which is a term used in science to refer to the time taken for half of a substance to decay
How to use "vivo half-life" in a sentence
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vivo half-life
Glycosylation may increase in vivo half-life or alter biological activity.
The isomers are also reported to have different in vivo half-life.
When in vivo half-life is desired to be increased, said antibodies can be modified.
The carbohydrate can be modified chemically to increase its in vivo half-life.
Second, peptides have a short in vivo half-life and are not useful therapeutically.
Firstly the present estrogenic substances exhibit an surprisingly long in vivo half-life.
For example, in vivo half-life may increase or dosage requirements may be reduced.
Another aspect of this invention is to improve the in vivo half-life of insulins.
The longer in vivo half-life corresponded to a longer retention time in the FcRn chromatography.
The most preferred property that may be optimized is the in vivo half-life.
This has been found to prolong the in vivo half-life of the peptide-chelator conjugate.
The glycoprotein can additionally be modified chemically to increase their in vivo half-life.
In contrast, the normal in vivo half-life of factor Xa is only about thirty seconds.
Therefore, simple alternative approaches are needed to improve the in vivo half-life of biotherapeutics.
Preferably, the in vivo half-life is determined in a human subject.
See also
Furthermore, these single domains have been shown to have a very short in vivo half-life.
In one embodiment, the agent exhibits an in vivo half-life of between 6 hours and 7 days.
However, these single domains have been shown to have a very short in vivo half-life.
The in vivo half-life of human VWF in the human circulation is approximately 12 hours.
Exemplary heterologous moieties are moieties that increase the in vivo half-life of the molecule.
In vivo half-life of FSH mutants.
Thus, chemical or enzymatic hydrolysis leads to a very short in vivo half-life for peptides.
The hydroxyl radical has a very short in vivo half-life of approximately 10-9 seconds and a high reactivity.
Another concern was that this alteration might adversely effect the in vivo half-life.
Efficacy of EPO is proportional to in vivo half-life thereof.
In some aspects, the proteinaceous heterodimers of the present disclosure have long in vivo half-life.
In another embodiment, the agent exhibits an in vivo half-life greater than 8 hours.
Factor VIII, von willebrand factor or complexes thereof with prolonged in vivo half-life.
Pharmacologic obstacle, The very brief in vivo half-life of decitabine.
Factor VIIa-polysialic acid conjugates having prolonged in vivo half-life.
In a further embodiment, the polypeptide linker exhibits an in vivo half-life greater than 8 hours.
Addition of transferrin to SCA significantly increases the in vivo half-life of SCA.
In one aspect, a domain antibody is formatted to increase its in vivo half-life.
CTLA4-lg immunoadhesins with enhanced binding to FcRn for extended in vivo half-life.
Factor VIIa - ( poly ) sialic acid conjugate having prolonged in vivo half-life.
Thus, the conjugates of the invention significantly extend the in vivo half-life of SN-38.
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Examples of using Vivo
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Examples of in vivo somatic cell mutagenicity tests are
There is no convincing evidence for genotoxicity in vivo
In vivo and in vitro pharmacokinetic drug interactions
Examples of using Half-life
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The half-life was prolonged in these patients
There is no change in half-life during treatment
Each elimination phase determines a half-life
