Examples of 'sialylation' in a sentence
Meaning of "sialylation"
Sialylation refers to the process of adding sialic acid to molecules, such as proteins or lipids, which can modify their functions or interactions in biological systems
Show more definitions
- Any reaction that introduces a sialyl group into a molecule
How to use "sialylation" in a sentence
Basic
Advanced
sialylation
Calculating a percent sialylation for the protein.
Degree of sialylation affects their ability to survive in circulation.
This is beneficial in case a high degree of sialylation is aimed at.
Sialylation does not affect the isolation.
The various degree of sialylation is a principal feature.
This corrected number was then used to calculate percent sialylation.
In addition a correct sialylation profile is obtained.
The sialylation of the glycoprotein declined with increasing reactor scale.
This document does not assess the sialylation of apolipoproteins in healthy subjects.
Certain cell lines have been or may be modified to reduce or remove sialylation.
Process for controlling sialylation of proteins produced by mammalian cell culture.
The cell culture conditions are selected to achieve the desired level of sialylation.
How a respective low amount of sialylation can be achieved is described above.
The sialylation of the glycoprotein was found to decline with increasing reactor scale.
The processes provide an increased and consistent level of terminal sialylation of a glycoprotein.
See also
Sialylation can be important for the pharmacokinetics and efficacy of protein biotherapeutics.
Thus stradomer molecule having altered sialylation can be produced using similar methods.
One heterogeneity particularly problematic for production and use in human is the sialylation.
The selectins require sialylation and fucosylation of most carbohydrate ligands for recognition.
The technologies thereby focus on the maximization of the sialylation degree of a recombinant glycoprotein.
Conditions for maximal sialylation would be a considerable advantage for the manufacture of glycoprotein therapeutics.
The methods of the invention are useful for altering the sialylation pattern of glycoproteins.
Process for controlling sialylation of proteins produced by mammalian cell culture Field of the Invention.
Recombinant glycoproteins produced in CHO cells can exhibit variable glycosylation and sialylation.
In particular a certain degree and pattern of sialylation is difficult to achieve with these cells.
No significant difference in mobility was observed, indicating lack of sialylation in vivo.
Demonstrated potency and utility for improving sialylation and obtaining consistent sialylation patterns.
Sialylation affects the circulatory half-life and biodistribution of proteins.
Process parameters which influence the degree of sialylation include oxygen level and glucose level.
Here again, the sialylation of IgGs is necessary to observe an anti-inflammatory activity.
ManNAc therapy may increase sialic acid production and subsequently increase sialylation of glomerular proteins.
Impact of sialylation on CDC ability.
SUMMARY Described herein are methods for analyzing the sialylation of a protein.
Alternatively, sialylation can be increased by maintaining cells in a low ammonium environment.
Depending upon the transgenic plant system, natural sialylation of glycoproteins may occur.
Sialylation o f g-glycosidically glycoproteins.
A method for determining the sialylation content of a protein comprising,.
Sialylation regulates multimerisation of the receptor, which is known to influence binding to sulphated glycoproteins.
Alternatively, we provide for increasing sialylation by maintaining cells in a low ammonium environment.
Culture density, time and storage conditions such as temperature also influence sialylation.
In addition, sialylation levels can vary depending on the cell type used.
Cell density, time, and storage conditions such as temperature also influence sialylation.
It is well known that sialylation induces a serum-resistant state in many strains.
The invention relates to methods and kits for the analysis of the sialylation of gluco-proteins.
Increasing the terminal sialylation is believed to increase the half-life of the immunoglobulin.
Furthermore, culturing conditions during the expression which result in a low sialylation degree can be used.
Here the modification of mucin sialylation affects the physico-chemical properties of the mucosal barrier.
In one embodiment, Fc fusions are glycoengineered to alter the level of sialylation.
Alternatively, the invention provides for increasing sialylation by maintaining cells in a low ammonium environment.
In one aspect, Fc fusions are glycoengineered to alter the level of sialylation.
