Examples of 'sphingosine kinase' in a sentence
Meaning of "sphingosine kinase"
sphingosine kinase - an enzyme involved in sphingolipid metabolism
How to use "sphingosine kinase" in a sentence
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sphingosine kinase
Additional sphingosine kinase inhibitors are known.
The soluble fraction was used in the sphingosine kinase reaction.
Stimulation of sphingosine kinase activity by acidic phospholipids was examined.
Functions as an agonist of sphingosine kinase.
The sphingosine kinase may also be is a recombinant enzyme.
These columns resulted in purification of the recombinant sphingosine kinase to homogeneity.
The sphingosine kinase is a cell or membrane extract or may be purified.
The invention also provides methods for inhibiting sphingosine kinase in a cell.
Sphingosine kinase is a key regulatory enzyme in a variety of cellular responses.
Fingolimod is metabolised by sphingosine kinase to the active metabolite fingolimod phosphate.
Sphingosine kinase inhibitors.
The invention further provides a process for preparing sphingosine kinase inhibitors.
This is the first sphingosine kinase to be purified to homogeneity from a human source.
An antibody as contemplated herein includes any antibody specific to any region of sphingosine kinase.
The expression product of the human sphingosine kinase nucleic acid molecule is human sphingosine kinase.
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Sphingosine kinase is an important mediator of the actions of VEGF.
Only a single chromatographically identified sphingosine kinase isoform is present in HUVEC.
Sphingosine kinase and SIP play important roles in cancer pathogenesis.
The effect of calcium / calmodulin on sphingosine kinase activity was examined.
The Sphingosine Kinase The sphingosine kinase may be used under various conditions.
Figure 11 is an image of the purification of recombinant human sphingosine kinase.
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
Figure 2 is a graphical representation of anion exchange chromatography of human sphingosine kinase.
A human sphingosine kinase protein or a derivative, analogue, chemical equivalent or mimetic thereof.
For example, specific antibodies can be used to screen for sphingosine kinase proteins.
Sphingosine kinase, sphingosine kinase or said agent are referred to as the active ingredients.
Alternatively, chemical agonists may be specifically designed to mimic certain physiochemical properties of sphingosine kinase.
Where the same sphingosine kinase molecules are associated together, the complex is a homomultimer.
C, Purity of the isolated recombinant human sphingosine kinase.
This indicates that sphingosine kinase is an important molecule responsible for regulating cellular sphingosine-1-phosphate levels.
Sphingosine is then rapidly phosphorylated by sphingosine kinase ( SK ) to produce SIP.
Sphingosine kinase is responsible for S1P production in cells.
Moreover, PDGF induces high levels of sphingosine kinase activity and S1P generation in platelets.
Sphingosine kinase and S1P play important roles in cancer pathogenesis.
Parts or fragments include, for example, active regions of sphingosine kinase.
The purification of sphingosine kinase from human placenta is summarised in Table 4.
A kit according to claim 21, the kit further comprising the sphingosine kinase.
Sphingosine kinase activity was eluted with a NaCl gradient of 0 to 1M in the equilibration buffer.
Figure 4 is an image of SDS-PAGE of purified human placenta sphingosine kinase.
Sphingosine kinase activity was eluted with the same buffer and 0.4 ml fractions collected.
Figure 6 is a schematic representation of the strategy used to clone sphingosine kinase ( SPHK ) from HUVEC.
Sphingosine kinase inhibitors are a new category of drugs that reduce the generation of sphingosine-1-phosphate.
S1P is formed by phosphorylation of sphingosine by sphingosine kinase ( SK ).
Modest levels of endogenous sphingosine kinase activity were detected in vector-transfected cells ( Figure 4 ).
Figure 10 is an image of the expression of recombinant human sphingosine kinase in E . coli BL21.
Figure 5B compares the sphingosine kinase activity according to several quantities of DMSO ( % ).
Sphingosine is then rapidly phosphorylated by sphingosine kinase ( SK ) to produce S1P.
The cDNA sequence for sphingosine kinase is defined by the nucleotide sequence set forth in < 400 > 1.
Commentary, The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
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Creatine kinase can be checked if myalgias develop
Blood tests show elevated creatine kinase
Elevation of creatine kinase in blood is indicative of myositis
Examples of using Sphingosine
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Derivatives of sphingosine have been prepared in various patents
A compound consisting of an oligonucleotide conjugated to a sphingosine molecule
Sphingosine is formed via degradation of sphingolipid in the lysosome
