Examples of 't-pa' in a sentence
Meaning of "t-pa"
'T-PA' is a noun that stands for Tissue Plasminogen Activator, a protein involved in the breakdown of blood clots
How to use "t-pa" in a sentence
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t-pa
The activity of t-PA is increased in the presence of fibrin.
One particular thrombolytic agent of particular interest is t-PA.
Use of t-PA for these purposes is especially preferred.
Alternative splicing of the t-PA gene produces three transcripts.
The t-PA used is obtained from human melanoma cells.
As indicated earlier t-PA and plasmin are preferred.
After t-PA injection a substantial decrease in plasma activity was observed.
Satisfactory amounts of human t-PA are produced by transformed cell cultures.
Thrombin also activates fibrinolysis by vascular endothelium t-PA release.
The resulting t-PA protein retains the fibrinolytic activity.
Several techniques may be used for recovery of the t-PA.
Recombinant plasmids containing the t-PA gene fragment were identified.
A preferred finger domain is that of native t-PA.
The action of t-PA in vivo and in vitro can be inhibited by a serpin.
Fibrin has been found to strongly stimulate plasminogen activation by t-PA.
See also
Finally administration of t-PA by means of a bolus injection has thrombolytic advantages.
The proposed disulfide pattern is by analogy to t-PA.
The amount of mutant t-PA to employ can be determined by routine experimentation.
Bowes melanoma cells were the original source of purified t-PA.
Plasma levels of t-PA protein were determined by a sandwich-type enzyme immunoassay.
The amino acid sequence of various native forms of t-PA are known.
As discussed above, t-PA variants are preferably produced by means of specific mutation.
The resulting slope of absorbance versus time is proportional to t-PA activity.
The injected amount of t-PA was in 3 x molar concentration of the administered antibody.
The involvement of carbohydrates in the clearance of t-PA has also been studied.
Production of mature t-PA lacking one or more of the carbohydrate chains.
Therefore, several variants have been proposed or devised to enhance specific properties of t-PA.
One of the most significant risks of t-PA treatment is uncontrolled bleeding.
The t-PA precipitate was collected from the dialyzed sample by centrifugation.
Various workers have modified t-PA in attempts to enhance its clinical suitability.
The t-PA is the main enzyme responsible for plasminogen conversion to plasmin.
Some of these alterations result in t-PA analogs which can be cleaved by thrombin.
Levels of t-PA in the plasma were determined using a sandwich-type enzyme immunoassay.
Another object of the present invention is to provide genes encoding improved t-PA.
Plasminogen is activated by t-PA to plasmin which is the fibrinolytically active enzyme.
Transfected cells were selected with methotrexate and screened for production of t-PA.
Combination of the t-PA cDNA with the beta globin fragment.
All of these conditions are met in present clinical standard therapy with t-PA.
Screening for a t-PA mutant which is resistant to inhibition by its cognate inhibitor.
Titration of standardized t-PA preparations.
A gene encoding a t-PA mutant as claimed in any one of the preceding claims.
Such mutations will enhance the clinical suitability of the t-PA analogs.
The t-PA analogs may further include a variety of substitutions and modifications.
Time to reperfusion is measured from the time of the first t-PA injection.
The modified t-PA of the invention is understood to include such glycosylated variations.
This missing triad may also contribute to higher intrinsic activity of pro-UK or t-PA.
The t-PA enzyme is composed of several domains with homologies to other proteins,.
Furthermore, the novel proteins have a prolonged in vivo stability as compared to authentic t-PA.
The stability of t-PA is also dependent upon the concentration of non-ionic surfactants.
The latter two antibodies are directed against the second kringle domain ot t-PA.
