Examples of 'tyrosine kinase activity' in a sentence
Meaning of "tyrosine kinase activity"
This phrase refers to a biochemical process involving the enzyme tyrosine kinase. It represents the ability of this enzyme to catalyze the transfer of phosphate groups to specific tyrosine residues in proteins, regulating various cellular signaling pathways. It is commonly studied in the field of molecular biology and biochemistry
How to use "tyrosine kinase activity" in a sentence
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tyrosine kinase activity
The protein possesses tyrosine kinase activity.
Tyrosine kinase activity in membranes.
Each of these receptor molecules have tyrosine kinase activity.
Measuring the tyrosine kinase activity of said protein.
The compounds of the invention are inhibitors of protein tyrosine kinase activity.
It has tyrosine kinase activity.
The mutant proteins also retained an active tyrosine kinase activity.
This tyrosine kinase activity then initiates a cascade of intracellular processes.
Various assays have been developed which measure tyrosine kinase activity.
Inhibition of tyrosine kinase activity would result in a reduced absorbance signal.
Binding of the ligand activates the tyrosine kinase activity of the receptor.
Thus receptor tyrosine kinase activity initiates a cellular signalling pathway leading to proliferation.
The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity.
Receptors with tyrosine kinase activity have a similar molecular topology.
This construct determines the ability of a test compound to inhibit tyrosine kinase activity.
See also
The polyoma virus affects tyrosine kinase activity inside the nuclear matrix.
Expression in an appropriate expression system can produce a polypeptide with tyrosine kinase activity.
Disordered increase in the tyrosine kinase activity causes abnormal differentiation and proliferation of cells.
Ligand binding induces dimerization which activates the tyrosine kinase activity of the receptor.
By inhibiting the tyrosine kinase activity of these proteins the disease process may be disrupted.
These are then expressed in a suitable expression system to obtain polypeptide with tyrosine kinase activity.
This provides a generic assay for measuring tyrosine kinase activity of any tyrosine kinase of interest.
Field of the Invention This invention relates to compounds that inhibit protein tyrosine kinase activity.
All of these have the intrinsic tyrosine kinase activity which is necessary for signal transduction.
The Ret protein is a transmembrane receptor with tyrosine kinase activity.
By measuring the tyrosine kinase activity with an assay such as that from Chemicon International.
A preferred active Src protein exhibits tyrosine kinase activity as well.
FAK have also tyrosine kinase activity and originally identified as a substrate for the oncogene protein.
A preferred inactive Src protein exhibits reduced tyrosine kinase activity as well.
Flt3 receptor tyrosine kinase activity is implicated in leukemias and myelodysplastic syndrome.
A preferred inactive Src or Yes protein exhibits reduced tyrosine kinase activity as well.
The B subunits contain a tyrosine kinase activity and the ATP binding sites.
The imidazopyrimidine derivatives and triazolopyrimidine derivatives of the present invention inhibit Syk tyrosine kinase activity.
Often, this is a tyrosine kinase activity.
Exemplary VEGF receptor antagonists include inhibitors of VEGF receptor tyrosine kinase activity.
Tyrosine kinase activity in the nucleus involves cell-cycle control and properties of transcription factors.
A preferred active Src or Yes protein exhibits tyrosine kinase activity as well.
This tyrosine kinase activity increases the phosphotyrosine content of many receptor-like and cytoplasmic regulatory proteins.
The compounds represented by Structural Formula I are useful as inhibitors of tyrosine kinase activity.
The ability to inhibit the p56 lck tyrosine kinase activity of compounds disclosed herein is described.
More specifically, in treating cancer involving inappropriate tyrosine kinase activity.
Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.
We conclude that porcine coronary artery tissue contains src-related tyrosine kinase activity.
C-Kit has tyrosine kinase activity and is required for normal hematopoiesis.
Members of this receptor family are membrane-associated proteins that exhibit tyrosine kinase activity.
Screening format, Tyrosine kinase activity is being measured using a synthetic peptide substrate.
This family of dual-specificity kinases has both serine / threonine and tyrosine kinase activity.
Elevated tyrosine kinase activity weakens cell-cell contacts and promotes ECM adhesions.
In a specific embodiment, the mutant EGFR activity is a tyrosine kinase activity.
These compounds inhibit the tyrosine kinase activity of growth factor receptors such as HER2.
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Examples of using Kinase
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Creatine kinase can be checked if myalgias develop
Blood tests show elevated creatine kinase
Elevation of creatine kinase in blood is indicative of myositis
Examples of using Activity
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There is a lot of activity happening in that room
Activity cards divided into four themes
Refrain from physical activity until symptoms are gone
Examples of using Tyrosine
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Tyrosine must be determined in hydrolysates of unoxidised samples
The protein possesses tyrosine kinase activity
Tyrosine hydroxylase can also be regulated by inhibition
