Examples of 'fc receptor' in a sentence
Meaning of "fc receptor"
The term 'Fc receptor' refers to a type of protein molecule found on certain immune cells. It stands for 'fragment constant receptor' and plays a crucial role in the immune system's response to antibodies. Fc receptors bind to the Fc region of antibodies, enabling immune cells to recognize and eliminate foreign substances, pathogens, or abnormal cells
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- a protein found on the surface of certain immune and blood cells that binds to antibodies attached to infected cells or invading pathogens, enabling antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity (ADCC)
How to use "fc receptor" in a sentence
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fc receptor
Fc receptor protein is purified by affinity purification from cell lysates.
Potency assays for antibody drug substance binding to an fc receptor.
Fc receptor binding was controlled for by using an excess of normal human serum.
In one embodiment the activating Fc receptor is FcyRIIIa.
Fc receptor binding signals the cytotoxic cell to kill the target cell.
In a particular embodiment the Fc receptor is an FcY receptor.
Fc receptor binding signals the effector cell to kill the target cell.
Immunoglobulin constant region Fc receptor binding agents.
Each Fc receptor binds immunoglobulins of a specific type.
In one embodiment the activating Fc receptor is an FcY receptor.
Fc receptor binding signals the NK cell to kill the target cell.
In one embodiment the activating Fc receptor is a human receptor.
Detecting the amount of FcR binding peptide bound to the Fc receptor.
The antibody can be employed to modulate Fc receptor levels on monocytic cells.
The Ig could have also the site of binding to an optionally mutated Fc receptor.
See also
In a preferred embodiment the Fc receptor binding region of the linker antibody is deleted.
The receptor may be an Fc receptor.
The adsorbed Fc receptor protein can be eluted with a mildly acidic elution buffer.
The intracellular domain may comprise an Fc receptor or a portion thereof.
A binding member with an Fc variant region may have enhanced binding to an Fc receptor.
There are a few different molecular species of Fc receptor to which human IgG binds.
In one embodiment the increased effector function is increased binding to an activating Fc receptor.
The immobilized variant is then contacted with an Fc receptor and a candidate compound.
In one embodiment the reduced effector function is reduced binding to an activating Fc receptor.
Antigen binding molecules with increased Fc receptor binding affinity and effector function.
Modified antibodies can be produced which have a reduced interaction with an Fc receptor.
The Fc receptor specificity mediates linkage to the effector cell through a known cytotoxic trigger molecule.
This phosphorylation reaction typically follows interaction of an Fc receptor with its ligand.
In some embodiments the Fc receptor is an activating Fc receptor.
In this context IgE binds strongly to mast cells through its Fc receptor.
In some embodiments the Fc receptor is a human Fc receptor.
An Fc variant antibody may sometimes have reduced binding to the Fc receptor FcgammaRIIB.
Fc receptor profiles were assayed using FACS.
The Fc variants disclosed herein may be optimized for a variety of Fc receptor binding properties.
Antigen and Fc receptor signaling.
In one embodiment the second polypeptide has low or no affinity for the Fc receptor.
To increase Fc receptor binding.
Serum immunoglobulin does not compete with the antibody for binding to the Fc receptor.
Fc receptor internalisation also allows efficient antigen presentation to stimulate T cell responses.
A therapeutic peptide may also provide its therapeutic effect through the binding to an Fc receptor.
In some embodiments, Fc receptor is a member of FcY receptor family.
Activation occurs when the Fc domain is bound by a cognate Fc receptor.
An antibody may not bind to an Fc receptor and / or complement factors.
The Fc variant protein may have enhanced binding to an Fc receptor.
In one embodiment the activating Fc receptor is FcyRIIIa, particularly human FcyRIIIa.
The Fc variant protein may have reduced binding to an Fc receptor.
For example, Fc receptor Y-chain is preferable to use as a cell membrane protein.
The Fc variant protein may have enhanced binding to the Fc receptor FcYRIIIA.
CD20 antibodies with increased fc receptor binding affinity and effector function.
The Fc variant protein may have reduced binding to the Fc receptor FcYRIIIA.
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