Examples of 'fc region' in a sentence
Meaning of "fc region"
fc region: In the context of biology, it refers to the constant region of an antibody that interacts with cell surface receptors or other effector molecules
How to use "fc region" in a sentence
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fc region
Fc region is marked by italic.
A method for the mass production of immunoglobulin fc region deleted initial methionine residues.
Fc region variants.
A carbohydrate attached to an Fc region of an antibody may be altered.
The Fc region may have reduced fucosylation.
The secondary antibody targets that Fc region.
Of the specific Fc region positions identified herein.
The antibody or fragment does not comprise an Fc region.
The protein may comprise an Fc region or a portion thereof.
The Fc region is central to the effector functions of antibodies.
Substitutions are introduced in the Fc region of the starting polypeptide.
The Fc region is essential to the effector functions of antibodies.
Furthermore the oligosaccharides of the Fc region are preferably bisected.
A parent polypeptide of the invention is a polypeptide comprising an Fc region.
Suitably the Fc region is derived from human IgG.
See also
Described herein are formulations of proteins comprising a variant Fc region.
Comprises a variant Fc region and has reduced fucosylation or is afucosylated.
The polypeptide may further comprise an antibody Fc region.
A native Fc region is homodimeric and comprises two polypeptide chains.
Fc receptors are proteins that bind the Fc region of antibodies.
The Fc region is also involved in activation of the complement cascade.
The immunoglobulin heavy chain constant region is an Fc region.
The carbohydrate moiety of the Fc region of an immunoglobulin may be utilized.
The carrier protein can be an Fc region.
In another embodiment the Fc region can be a murine immunoglobulin gene.
Fc receptors bind to the Fc region.
The Fc region can be linked to its partner with or without a spacer.
Conjugation typically occurred at the Fc region of the antibody.
The Fc region of an IgG antibody has two carbohydrate binding sites.
The present invention concerns polypeptides comprising variants of an Fc region.
In one embodiment of the disclosure the Fc region is a human Fc region.
The Fc region comprises specific modifications at various amino acid positions.
One such modification is the use of the Fc region of immunoglobulins.
The corresponding Fc region of other immunoglobulins can be identified by sequence alignments.
The a chain thereof which is responsible for binding an Fc region.
One example is the replacement of a Fc region with that of a different isotype.
The Fc region enables antibodies to interact with the immune system.
Amino acid modifications may be made to the Fc region of an immunoglobulin.
An immunoglobulin Fc region overexpressed as inclusion bodies may be purified through a general technique.
The preferred dimerization domain includes an Fc region or a hinge region.
Native Fc region polypeptides or muteins thereof may be employed in making these constructs.
DNA encoding a mutein of the Fc region of a human IgGl antibody was isolated.
The alpha chain thereof which is responsible for binding an Fc region.
The FcYRs bind the IgG Fc region with different affinities.
The binding of a heteroantibody to FcR is mediated by the Fc region of the antibody.
The Fc region is further engineered to increase the stability of the aglycosylated molecule.
The second polypeptide can include the Fc region of an immunoglobulin polypeptide.
Fc polypeptides of the present invention also include fragments of the Fc region.
The antibodies can be modified in the Fc region to provide desired effector functions.
The present invention provides formulation of proteins comprising a variant Fc region.
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