Examples of 'fc regions' in a sentence
Meaning of "fc regions"
FC regions: Refers to the fragment crystallizable regions of antibodies, which play a key role in immune responses
How to use "fc regions" in a sentence
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fc regions
Fc regions may also be linked genetically.
Identification and engineering of antibodies with variant fc regions and methods of using the same.
Fc regions may be linked using a chemical engineering approach.
Of interest in cases described herein are the Fc regions.
Fc regions are essential to the participation of complements.
Of interest in embodiments described herein are the Fc regions.
Fc regions also include variants that do not result in alterations to biological function.
Preferred immunoglobulins include Fc regions or portions thereof.
Peptibodies are essentially peptide fusions with antibody Fc regions.
Examples of variant Fc regions are detailed herein.
Of interest in the present invention are the Fc regions.
There are many methods of modifying Fc regions that are known in the art.
Gray highlights indicate modifications from native IgG Fc regions.
Some specific aspects of variant Fc regions are detailed infra.
The invention encompasses molecules that are homodimers or heterodimers of Fc regions.
See also
Interactions between Fc regions of antibody molecules promote rapid precipitation of immune complexes.
Optionally the cell produces antibodies having hypofucosylated Fc regions.
Recombinant fusión proteins comprising Fc regions of IgG antibodies are likely to form dimers.
The Fc regions of native IgGs also include mutants spontaneously produced from them.
Attachment of biological agents via carbohydrate moieties on Fc regions is also contemplated.
The variant Fc regions of the present invention may be part of larger molecules.
Methods for generating non naturally occurring Fc regions are known in the art.
Fc receptors are molecules which bind specifically to active molecular sites within immunoglobulin Fc regions.
The endosomal compartment then recycles the Fc regions to the cell surface.
Monoclonal antibodies The present invention provides monoclonal antibodies with variant Fc regions.
The five different types of Fc regions allow antibodies to be grouped into five isotypes.
Cleavage typically occurs in a flexible hinge region joining the Fab and Fc regions.
The term encompasses heterodimeric Fc regions where each of the constituent Fc domains is different.
The present invention provides humanized and human antibodies with variant Fc regions.
The carbohydrate moiety present in the Fc regions of antibodies is a convenient location for conjugation.
Nucleic acid sequences may be mutated such that variant Fc regions may be produced.
IgG Fc regions also contain a hinge region see Janeway et al.
Phagocytes bind those Fc regions with their Fc receptors.
In another case immunoglobulins disclosed herein are isolated Fc regions or Fc fragments.
Fc regions are responsible for prolonging the antibody half-life in the plasma.
The term includes native Fc regions and variant Fc regions.
Polyclonal Antibodies The present invention provides polyclonal antibodies with variant Fc regions.
Variant Fc regions.
Fc regions may be linked using disulfide engineering and / or chemical cross-linking.
The flexible hinge that links the Fab and Fc regions is not shown.
Fc regions are present, for example, in human or humanized tetrameric monoclonal IgG antibodies.
The resulting nucleotide sequences encoding the recombinant immunoglobulin Fc regions are represented by SEQ.
In one embodiment, Fc regions may be linked genetically.
In another embodiment, at least two of the Fc regions are different.
Suitably, Fc regions may be linked genetically.
In some aspects, the glycosylation of Fc regions may be modified.
Suitably, Fc regions may be linked using a chemical engineering approach.
Figure 3 depicts alignments of native sequence IgG Fc regions.
In a preferred embodiment, Fc regions maybe linked genetically.
The Fc regions of the invention is derived from human IgG1.
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