Examples of 'fc variant' in a sentence
Meaning of "fc variant"
fc variant ~ a specific version or mutation of a gene or organism that is associated with a particular trait or characteristic
How to use "fc variant" in a sentence
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fc variant
The immunoadhesins herein preferably comprise an Fc variant.
The context of the Fc variant drammatically impacts the desired specificity.
Consequently a variant of interest comprises an Fc variant.
Fusion partners may be linked to the Fc variant sequence vía a linker sequences.
The portion of an immunoglobulin constant region can include an Fc variant.
The Fc variant protein may have ligand relative to a comparable molecule.
Different glycosylation profiles among the Fc variant antibody panel were observed.
An Fc variant antibody may sometimes have reduced binding to the Fc receptor FcgammaRIIB.
The antibody variant of the present invention means a protein having a Fc variant as claimed.
A binding member with an Fc variant region may have enhanced binding to an Fc receptor.
The Fc fragment of an immunoglobulin constant region can be an Fc variant.
Affinities of Fc variant antibodies for human FcyRs as determined by Biacore surface plasmon resonance.
Differential MAb activity according Fc variant.
An Fc variant antibody may have increased affinity for an Fc ligand.
An Fc domain as used herein encompasses native Fc and Fc variant molecules.
See also
The Fc variant protein may have enhanced binding to an Fc receptor.
Polynucleotides A polynucleotide is provided which encodes an IgG Fc variant domain containing polypeptide.
Affinities of Fc variant antibodies for human FcyRs as determined by Biacore.
The Fc component is either a native Fc or an Fc variant.
The Fc variant protein may have reduced binding to an Fc receptor.
A variant protein according to para 1 wherein said Fc variant further comprises an engineered glycoform.
An Fc variant antibody may sometimes have decreased affinity for an Fc ligand.
In a specific embodiment, the Fc variant protein has reduced binding to an Fc receptor.
An Fc variant protein may have reduced ADCC activity relative to a comparable molecule.
In a specific embodiment, the Fc variant protein has enhanced binding to an Fc receptor.
An Fc variant protein may have enhanced CDC activity relative to a comparable molecule.
Briefly, various concentrations of Fc variant and human complement may be diluted with buffer.
The Fc variant protein may have enhanced binding to the Fc receptor FcYRIIIA.
In various embodiments, the Fc component is either a native Fc or an Fc variant.
The Fc variant protein may have reduced binding to the Fc receptor FcYRIIIA.
Table 8 hereunder indicates the concentration of each Fc variant used for performing ELISA assays.
The Fc variant protein may have reduced binding to the Fc receptor FcRn.
Biacore surface plasmon resonance sensorgrams showing binding of Fc variant anti-CD19 antibodies to human FcYRIIb.
That is, Fc variant proteins are not added exogenously to the cells.
G In certain disclosures, the Fc variant comprises a CH2 domain.
The Fc variant protein may have enhanced binding to C1q relative to a comparable molecule.
See, Table 4 for the list of Fc variant heterodimers and the Tm values.
The Fc variant protein may have enhanced serum half-life relative to comparable molecule.
The Fc-phage is bacteriophage M13 which expresses an Fc variant on its capsid.
In a preferred embodiment, Fc variant proteins are purified or isolated after expression.
Figure 36, Differential MAb activity according Fc variant.
In other embodiments, the Fc variant provides an engineered cysteine residue.
Fc variant anti-IgE antibodies were tested for their capacity to inhibit IgE+ B cells.
In certain aspects, an Fc variant biMab has increased affinity for an Fc ligand.
Expression of Fc variant and wild type ( WT ) proteins of alemtuzumab in 293T cells.
In one embodiment said Fc variant of a human IgG Fc polypeptide is an Fc-fusion.
Alternatively, the Fc variant can be synthesized in an acellular system ( e.g., chemically synthesized ).
In some aspects, an IgG Fc variant domain containing polypeptide is conjugated to a therapeutic agent.
In a specific aspect, an Fc variant biMab has reduced binding to the Fc receptor FcYRIIIA.
In a specific aspect, an Fc variant biMab has enhanced binding to the Fc receptor FcYRIIIA.
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