Examples of 'fc variants' in a sentence
Meaning of "fc variants"
fc variants: This phrase likely refers to different versions or types of FC, which could stand for various things such as 'Fibre Channel' or 'Football Club'. It denotes variations, alternatives, or diverse forms within the context of FC
How to use "fc variants" in a sentence
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fc variants
Fc variants with altered binding to FcRn.
Summary of FcRn binding properties of the Fc variants.
Fc variants with reduced effector functions.
Fusion partners may enable Fc variants to be labeled.
Fc variants are described in further detail hereinafter.
Particularly preferred are Fc variants as described herein.
Fc variants have one or more glycosylation sites removed.
Soluble peptides disclosed herein may be fused to Fc variants.
Optimized fc variants and methods for their generation.
In vivo models have proved useful in the study of Fc variants.
Fc variants that enhance affinity for an inhibitory receptor FcyRllb may also be used.
This exemplary assay allows for preclinical evaluation of Fc variants in vivo.
Fc variants disclosed herein are defined according to the amino acid modifications that compose them.
The present invention is directed to optimized Fc variants useful in a variety of contexts.
Fc variants may be constructed in a parent Fc polypeptide irrespective of its context.
See also
There is still a need in the art for novel optimized Fc variants.
Synergy of Fc variants and engineered glycoforms.
Methods for producing and optionally recovering the Fc variants are disclosed.
Binding assays of Fc variants of the present invention to FcRn.
The present invention also provides methods for engineering optimized Fc variants.
Capacity of select Fc variants to mediate binding and activation of complement.
Summary of surface plasmon resonance experiments of Fc variants with improved binding to FcRn.
Also provided are Fc variants with conservative amino acid substitutions.
Optimization is designed for rapid attachment of all Fc variants to each new Fv region.
The Fc variants of the present invention may find use in an Fc fusión.
Also described herein are isolated nucleic acids encoding the Fc variants described herein.
Described herein are Fc variants that comprise modified glycoforms or engineered glycoforms.
The present invention provides isolated nucleic acids encoding the Fc variants described herein.
The Fc variants of the present invention may find use in an antibody.
The present application describes isolated nucleic acids encoding the Fc variants described herein.
The Fc variants of the present invention may be used as immunomodulatory therapeutics.
Coli expression of the Fc variants.
Protein titers of the Fc variants were assessed by Coomassie blue staining of a polyacrylamide gel.
AlphaScreen assay showing binding of select alemtuzumab Fc variants to human FcYRIIb.
The Fc variants of the present invention may be optimized for a variety of properties.
AlphaScreen assay showing binding of select alemtuzumab Fc variants to human FcyRllb.
Other Fc variants comprising insertions or deletions have decreased affinity for FcRn.
The present invention also provides Fc variants with reduced CDC function.
The Fc variants of the present invention may be used for various therapeutic purposes.
The present invention further provides Fc variants with enhanced CDC function.
The Fc variants of the present invention may find use in a wide range of products.
FcRn binding data of Fc variants.
The Fc variants disclosed herein may be optimized for a variety of Fc receptor binding properties.
As noted above, Fc variants are described.
The Fc variants of the present invention may comprise more than one protein chain.
This may be particularly favorable for anti-cancer Fc variants.
The Fc variants disclosed herein may be optimized to possess enhanced affinity for human FcYRIIIb.
As for FcRn variants, the Fc variants can reside on either strand.
Fc variants may be desirable for a number of reasons, several of which are described below.
Currently, such Fc variants do not exist in the art.
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