Examples of 'internucleoside linkages' in a sentence
Meaning of "internucleoside linkages"
internucleoside linkages: Refers to chemical bonds between nucleosides, which are compounds consisting of a nitrogenous base linked to a sugar. This phrase is commonly used in biochemistry and molecular biology
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internucleoside linkages
The internucleoside linkages of each compound are phosphorothioate throughout.
Subscript s represents a phosphorothioate internucleoside linkages.
The internucleoside linkages are phosphorothioate linkages.
Certain types of carbamate internucleoside linkages are known in the art.
The internucleoside linkages constitute the backbone of a nucleic acid molecule.
Oligonucleotides containing phosphorothioate internucleoside linkages have been shown to be more stable in vivo.
All internucleoside linkages are phosphorothioate internucleoside linkages unless otherwise indicated.
The phosphoramidite approach has been used to synthesize oligonucleotides having a variety of modified internucleoside linkages.
Internucleoside linkages are phosphorothioate.
Included among such oligonucleotides are chimeric oligonucleotides having different types of modified internucleoside linkages.
Other modified internucleoside linkages include at least one phosphorothioate linkage.
Antisense compounds targeted to a huntingtin nucleic acid comprise one or more modified internucleoside linkages.
In certain instances, the modified internucleoside linkages are phosphorothioate linkages.
In certain instances, antisense oligonucleotides have at least 3 modified internucleoside linkages.
In certain embodiments, the modified internucleoside linkages are phosphorothioate linkages.
See also
In certain embodiments, oligonucleotides comprise a region of uniformly modified internucleoside linkages.
In some embodiments, the modified internucleoside linkages are phosphorothioate linkages.
In certain embodiments, the oligonucleotide is uniformly linked by phosphorothioate internucleoside linkages.
Internucleoside linkages having a chiral atom can be prepared racemic, chiral, or as a mixture.
In certain embodiments, the oligonucleotide comprises at least 8 phosphorothioate internucleoside linkages.
In certain embodiments, the modified internucleoside linkages are interspersed throughout the antisense compound.
In certain embodiments, antisense oligonucleotides have at least 3 modified internucleoside linkages.
Representative chiral internucleoside linkages include, but are not limited to, alkylphosphonates and phosphorothioates.
A nucleic acid can comprise a modified backbone and / or modified internucleoside linkages.
The remainder of the sugars, nucleobases and internucleoside linkages can be independently modified or unmodified.
Oligonucleotides include oligonucleotides containing modified backbones or non-natural internucleoside linkages.
The internucleoside linkages are phosphorothioate throughout the oligonucleotide and all cytidine residues are 5-methylcytidines.
More particularly, the invention relates to sulfurization of the internucleoside linkages of oligonucleotides.
Certain Internucleoside Linkages In certain embodiments, the present disclosure provides oligonucleotides comprising linked nucleosides.
Particularly useful oligonucleotides are linked with phosphorothioate and / or phosphorodithioate internucleoside linkages.
The oligonucleotide for use of claim 1, wherein said internucleoside linkages are phosphorothioate linkages.
Chimeric oligonucleotides contain deoxyribonucleosides only, but have regions containing different internucleoside linkages.
In some embodiments, all the internucleoside linkages in region A are other than phosphodiester.
The second type includes those analogs having non-phosphate internucleoside linkages.
All internucleoside linkages are phosphorothioate, and all cytidine residues are 5-methylcytidines.
The oligomer according to embodiment 42 wherein all the internucleoside linkages are phosphorothioate linkages.
In certain embodiments, oligonucleotides of the present disclosure comprise a region of uniformly modified internucleoside linkages.
The internucleoside linkages may be independently selected, or all be the same, i . e phosphorothioate linkages.
Specific examples of oligonucleotides include those containing modified backbones or non-natural internucleoside linkages.
Representative non-phosphate internucleoside linkages include siloxane, carbamate, carboxymethyl esters, acetamidate, carbonate and thioethers.
In preferred embodiments, the nonionic region contains alkylphosphonate and / or phosphoramidate and / or phosphotriester internucleoside linkages.
The internucleoside linkages throughout each gapmer are phosphorothioate ( P = S ) linkages.
This term includes oligonucleotides composed of naturally-occurring nucleobases, sugars and covalent internucleoside linkages.
In one embodiment, the internucleoside linkages of the oligonucleotide are N3 ' → P5 ' thiophosphoramidate linkages.
The second type includes replacement of the phosphodiester linkage with non-phosphate internucleoside linkages.
The antisense oligonucleotide according to any preceding claim, wherein the internucleoside linkages are phosphorothioate linkages.
A nucleic acid-targeting nucleic acid can comprise a modified backbone and / or modified internucleoside linkages.
A hybrid oligonucleotide according to any one of claims 1-5, wherein all internucleoside linkages are phosphorothioates linkages.
Oligonucleotides useful in this invention include oligonucleotides containing modified backbones or non-natural internucleoside linkages.
In certain embodiments, siRNA compounds may comprise unmodified RNA nucleosides, but modified internucleoside linkages.
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Examples of using Internucleoside
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Each internucleoside linkage is a phosphorothioate internucleoside linkage
In one embodiment the modified internucleoside linkage is phosphorothioate
The internucleoside linkages of each compound are phosphorothioate throughout
Examples of using Linkages
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