Examples of 'internucleoside linkage' in a sentence
Meaning of "internucleoside linkage"
internucleoside linkage: a connection between nucleosides in a biological context
How to use "internucleoside linkage" in a sentence
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internucleoside linkage
Each internucleoside linkage is a phosphorothioate internucleoside linkage.
In one embodiment the modified internucleoside linkage is phosphorothioate.
The internucleoside linkage may be a phosphorothioate internucleoside linkage.
A phosphorothioate linkage is a modified internucleoside linkage.
The modified internucleoside linkage may comprise a phosphorothioate linkage.
The oligonucleotide analog can have any type of internucleoside linkage.
Internucleoside linkage may be used interchangeably with internucleotide linkage.
In all the following oligonucleotides the internucleoside linkage is a phosphorothioate linkage.
The covalent linkage between two nucleosides may be referred to as an internucleoside linkage.
A preferred phosphorus containing modified internucleoside linkage is the phosphorothioate internucleoside linkage.
The modified oligonucleotide may comprise at least one modified internucleoside linkage.
The phosphite internucleoside linkage is then oxidized using a suitable oxidizing agent.
The first and second ester bond represent the internucleoside linkage.
In another embodiment each internucleoside linkage of the antisense oligonucleotide is a phosphorothioate internucleoside linkage.
The antisense oligonucleotide of any preceding claim having at least one modified internucleoside linkage.
See also
The internucleoside linkage may be the natural occurring phospodiester linkage or a derivative thereof.
An S following a nucleotide denotes a backbone modification consisting of a phosphorothioate internucleoside linkage.
The internucleoside linkage can be the natural occurring phospodiester linkage or a derivative thereof.
In one embodiment the ORN further comprises at least one modified internucleoside linkage.
In certain embodiments, a modified internucleoside linkage comprises a phosphorus atom.
In certain embodiments, antisense oligonucleotides have at least one modified internucleoside linkage.
In certain embodiments, each internucleoside linkage is a phosphorothioate internucleoside linkage.
Usually, the mononucleotides are linked through an internucleoside linkage.
In certain embodiments, the internucleoside linkage is a phosphorothioate internucleoside linkage.
For example, a phosphorothioate linkage is a modified internucleoside linkage.
In some embodiments, each internucleoside linkage is a phosphorothioate internucleoside linkage.
A “ chimeric oligonucleotide ” is an oligonucleotide having more than one type of internucleoside linkage.
In certain instances, each internucleoside linkage is a phosphorothioate internucleoside linkage.
In such embodiments, nucleosides may be linked together using any internucleoside linkage.
In certain embodiments, such modified internucleoside linkage is a phosphorothioate internucleoside linkage.
In certain embodiments, oligonucleotides comprise a region having an alternating internucleoside linkage motif.
In certain embodiments, at least one internucleoside linkage is a phosphorothioate internucleoside linkage.
In certain embodiments, a modified oligonucleotide comprises at least one phosphorothioate internucleoside linkage.
In certain embodiments, at least one internucleoside linkage is a modified internucleoside linkage.
In a particular example, the oligomer includes at least one phosphorothioate internucleoside linkage.
In certain instances, at least one internucleoside linkage is a phosphorothioate internucleoside linkage.
In certain embodiments, the compound has at least one modified internucleoside linkage.
In further embodiments, one or more internucleoside linkage can be optionally modified.
The internucleoside linkage may be of any type, and is preferably a phosphorothioate or phosphodiester linkage.
By " enzymatic linkage " is meant an internucleotide or internucleoside linkage formed by an enzyme.
In certain embodiments, each internucleoside linkage of an antisense compound is a phosphorothioate internucleoside linkage.
In certain embodiments, the modified oligonucleotide has at least one modified internucleoside linkage.
In some embodiments, at least one of the internucleoside linkage in the oligomer is phosphodiester.
The oligonucleotide of any preceding claim, comprising at least one modified internucleoside linkage.
The compound of claim 4, wherein each internucleoside linkage is a phosphorothioate internucleoside linkage.
The antisense oligonucleotide of claim 1 having at least one modified internucleoside linkage or nucleobase.
In other embodiments, each internucleoside linkage of an antisense compound is a phosphorothioate internucleoside linkage.
In certain embodiments, the modified oligonucleotide comprises at least one modified internucleoside linkage.
Most preferably, the phosphoramidate internucleoside linkage is a primary phosphoramidate internucleoside linkage.
In certain embodiments, the antisense compound comprises at least one modified internucleoside linkage.
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Examples of using Internucleoside
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Each internucleoside linkage is a phosphorothioate internucleoside linkage
In one embodiment the modified internucleoside linkage is phosphorothioate
The internucleoside linkages of each compound are phosphorothioate throughout
