Examples of 'internucleotide' in a sentence
Meaning of "internucleotide"
Internucleotide (noun) - refers to the portion of a nucleic acid molecule that lies between adjoining nucleotide units, such as between two nucleotides in a DNA or RNA strand
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- Between nucleotides
How to use "internucleotide" in a sentence
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internucleotide
All of the internucleotide linkages are phosphorothioate linkages.
The bases react to form an internucleotide phosphite bond.
The internucleotide linkages of each compound are phosphorothioate throughout.
In one embodiment the stabilized internucleotide linkages are phosphorothioate.
Internucleotide linkages of the oligonucleotide may all be phosphorothioate linkages.
Formation of the internucleotide bond.
Each internucleotide linkage in an internal dinucleotide is an internal internucleotide linkage.
In some embodiments all the internucleotide linkage groups are phosphorothioate.
The sequences optionally contain phosphorothioate modified internucleotide linkages.
Phosphodiester internucleotide linkages are afforded by oxidation with aqueous iodine.
Stereospecific modification of internucleotide linkage.
Phosphodiester internucleotide linkages were afforded by oxidation with aqueous iodine.
The sequences preferably contain phosphorothioate modified internucleotide linkages.
Each internucleotide position was phosphorothioated.
Internucleoside linkage may be used interchangeably with internucleotide linkage.
See also
Stabilized internucleotide linkage.
The invention also relates to oligonucleotides having chiral internucleotide linkages.
Other internucleotide bonds which stabilise the oligonucleotide may be used.
Part of the phosphodiester groups in its internucleotide skeleton is replaced by phosphorothioate groups.
Other internucleotide bonds which stabilize the oligonucleotide may also be used.
This substitution creates a phosphorothioate internucleotide linkage in place of the phosphodiester linkage.
Oligonucleotides have typically been synthesized with the native phosphodiester internucleotide linkages.
One or more internucleotide linkages in the antisense oligonucleotide may be modified.
The modified oligonucleotide primer has at least one modified internucleotide linkage.
Many such modified internucleotide linkages have been described in the art.
The symbol in these structures refers to the presence of a phosphodiester internucleotide linkage.
In another embodiment all internucleotide linkages of the oligonucleotide are phosphorothioate linkages.
In one embodiment the stabilized backbone comprises a plurality of phosphorothioate internucleotide linkages.
This modification makes the internucleotide linkage resistant to nuclease degradation.
The RNAi agent may further comprise at least one phosphorothioate or methylphosphonate internucleotide linkage.
Phosphorothioate internucleotide bonds have also been created using polymerase and dNTPaS.
Also included within the scope of the invention are oligonucleotides with mixed internucleotide linkages.
In other embodiments each internucleotide linkage of the nucleic acid is a phosphodiester linkage.
These latter approaches have been used to synthesize oligonucleotides having a variety of modified internucleotide linkages.
A phosphodiester internucleotide linkage is the type of linkage characteristic of nucleic acids found in nature.
In other embodiments the agonist is nucleic acid having at least one phosphodiester internucleotide linkage.
Oligonucleotides connected by an internucleotide bond that refers to a chemical linkage between two nucleoside moieties.
Optionally every internal YG dinucleotide has a phosphodiester internucleotide linkage.
The compounds with selected internucleotide phosphodiester linkages have antiviral activity and increased metabolic stability.
In one embodiment every internal YZ dinucleotide has a phosphodiester internucleotide linkage.
The Preferred modified internucleotide linkage is an alkylphosphonothioate linkage.
The oligonucleotide of claim 3 having phosphorothioate internucleotide linkages.
In these Tables the internucleotide linkage is PS unless otherwise mentioned.
More preferred, all linkages are phosphorothioate internucleotide linkages.
In some embodiments, all of the internucleotide linkages are phosphorothioate linkages.
Cholesterol, aminoalkyl-linker or a phosphothioate at the first internucleotide linkage.
In another example, most of the internucleotide linkages are phosphorothioate.
Cholesterol, aminoalkyl-linker or a phosphorothioate at the first internucleotide linkage.
In another embodiment, most of the internucleotide linkages are phosphorothioate.
In a related instance, oligonucleotide comprises a backbone of phosphorothioate internucleotide linkages.
