Examples of 'internucleotide linkage' in a sentence
Meaning of "internucleotide linkage"
internucleotide linkage - a term used in genetics to describe the connection between nucleotides within a DNA or RNA molecule
How to use "internucleotide linkage" in a sentence
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internucleotide linkage
Each internucleotide linkage in an internal dinucleotide is an internal internucleotide linkage.
In some embodiments all the internucleotide linkage groups are phosphorothioate.
Internucleoside linkage may be used interchangeably with internucleotide linkage.
Stabilized internucleotide linkage.
The modified oligonucleotide primer has at least one modified internucleotide linkage.
This modification makes the internucleotide linkage resistant to nuclease degradation.
The symbol in these structures refers to the presence of a phosphodiester internucleotide linkage.
This substitution creates a phosphorothioate internucleotide linkage in place of the phosphodiester linkage.
The RNAi agent may further comprise at least one phosphorothioate or methylphosphonate internucleotide linkage.
In other embodiments each internucleotide linkage of the nucleic acid is a phosphodiester linkage.
Stereospecific modification of internucleotide linkage.
A phosphodiester internucleotide linkage is the type of linkage characteristic of nucleic acids found in nature.
In other embodiments the agonist is nucleic acid having at least one phosphodiester internucleotide linkage.
The Preferred modified internucleotide linkage is an alkylphosphonothioate linkage.
Optionally every internal YG dinucleotide has a phosphodiester internucleotide linkage.
See also
In these Tables the internucleotide linkage is PS unless otherwise mentioned.
In one embodiment every internal YZ dinucleotide has a phosphodiester internucleotide linkage.
The internucleotide linkage attached to the 3 ' end nucleotide is a phosphorothioate linkage.
Cholesterol, aminoalkyl-linker or a phosphothioate at the first internucleotide linkage.
A phosphorothioate at the first internucleotide linkage at the 3 ' end of the antisense and sense sequences.
Cholesterol, aminoalkyl-linker or a phosphorothioate at the first internucleotide linkage.
Oxidizing or sulfurizing the phosphite type internucleotide linkage obtained in step 1 into a phosphate linkage respectively ;.
An oligonucleotide of claim 3 comprising at least one phosphorothioate internucleotide linkage.
In another preferred embodiment the phosphodiester-like internucleotide linkage is diasteromerically pure Rp phosphorothioate.
An oligonucleotide according to claim 7 comprising at least one phosphorothioate internucleotide linkage.
Some internucleotide linkage analogs include morpholidate, acetal, and polyamide-linked heterocycles.
The oligonucleotide of claim 2 having at least one phosphorothioate internucleotide linkage.
The oligonucleotide includes at least 2 stabilized internucleotide linkages . " _ " represents phosphodiester or phosphodiester-like internucleotide linkage.
In another embodiment, the oligonucleotide comprises at least one phosphorothioate internucleotide linkage.
P * designates an internucleotide linkage to an adjacent monomer, or a 3 ' - terminal group ;.
The symbol * used in the formulas refers to the presence of a stabilized internucleotide linkage.
The method according to claim 5, wherein the non-phosphodiester internucleotide linkage is a phosphorothioate linkage.
In certain embodiments, short antisense compounds comprise at least one modified internucleotide linkage.
The at least one internal YG dinucleotide having a phosphodiester internucleotide linkage is CG or TG ;.
The oligonucleotide of claim 1, wherein said oligonucleotide comprises at least one phosphorothioate internucleotide linkage.
Y1 and Y2 each include at least one modified internucleotide linkage.
In particular embodiments, the modification group is attached creating a phosphotriester ( PTE ) internucleotide linkage.
The at least one internal YZ dinucleotide itself has a phosphodiester or phosphodiester-like internucleotide linkage.
PR, The R stereoconfiguration about a chiral phosphorous atom in a phosphorothioate internucleotide linkage.
An oligonucleotide as claimed in claim 2 ( a ), wherein every internal YG dinucleotide has a phosphodiester internucleotide linkage.
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All of the internucleotide linkages are phosphorothioate linkages
The bases react to form an internucleotide phosphite bond
The internucleotide linkages of each compound are phosphorothioate throughout
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