Examples of 'internucleotide linkages' in a sentence
Meaning of "internucleotide linkages"
internucleotide linkages: This term refers to the connections or bonds between nucleotides in nucleic acids like DNA or RNA.
How to use "internucleotide linkages" in a sentence
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internucleotide linkages
All of the internucleotide linkages are phosphorothioate linkages.
The sequences optionally contain phosphorothioate modified internucleotide linkages.
The internucleotide linkages of each compound are phosphorothioate throughout.
In one embodiment the stabilized internucleotide linkages are phosphorothioate.
Internucleotide linkages of the oligonucleotide may all be phosphorothioate linkages.
The sequences preferably contain phosphorothioate modified internucleotide linkages.
Phosphodiester internucleotide linkages are afforded by oxidation with aqueous iodine.
The invention also relates to oligonucleotides having chiral internucleotide linkages.
Phosphodiester internucleotide linkages were afforded by oxidation with aqueous iodine.
Oligonucleotides have typically been synthesized with the native phosphodiester internucleotide linkages.
One or more internucleotide linkages in the antisense oligonucleotide may be modified.
In one embodiment the stabilized backbone comprises a plurality of phosphorothioate internucleotide linkages.
Many such modified internucleotide linkages have been described in the art.
Also included within the scope of the invention are oligonucleotides with mixed internucleotide linkages.
In another embodiment all internucleotide linkages of the oligonucleotide are phosphorothioate linkages.
See also
These latter approaches have been used to synthesize oligonucleotides having a variety of modified internucleotide linkages.
In another example, most of the internucleotide linkages are phosphorothioate.
In a related instance, oligonucleotide comprises a backbone of phosphorothioate internucleotide linkages.
In another embodiment, most of the internucleotide linkages are phosphorothioate.
In a related embodiment, oligonucleotide comprises a backbone of phosphorothioate internucleotide linkages.
In some embodiments, all of the internucleotide linkages are phosphorothioate linkages.
The oligonucleotide of claim 3 having phosphorothioate internucleotide linkages.
In one embodiment, all internucleotide linkages are of the aforementioned types.
More preferred, all linkages are phosphorothioate internucleotide linkages.
Oligonucleotide comprising different internucleotide linkages are contemplated, e.g. mixed phosphorothioate phosphodiesters.
In one embodiment, these sequences contain phosphorothioate modified internucleotide linkages.
Oligonucleotide comprising different internucleotide linkages are contemplated, e.g. mixed phosphorothioate phophodiesters.
In certain aspects, the oligonucleotides may include modified internucleotide linkages.
In certain embodiments, all internucleotide linkages of the oligonucleotide are phosphorothioate linkages.
An oligonucleotide according to claim 4 wherein all linkages are phosphorothioate internucleotide linkages.
Oligonucleotides comprising different internucleotide linkages are contemplated, e.g. mixed phosphorothioate phophodiesters.
Thus a linear oligonucleotide that is n nucleotides long has a total of n-1 internucleotide linkages.
Examples of modified bonds or internucleotide linkages comprise phosphorothioate, phosphorodithioate or the like.
Hence, the term phosphorothioate refers to both phosphorothioate and phosphorodithioate internucleotide linkages.
The polynucleotide of claim 1, wherein all of the internucleotide linkages are phosphorothioate linkages.
More particularly, the invention relates to the synthesis of oligonucleotides having modified internucleotide linkages.
In yet another embodiment, all internucleotide linkages of the oligonucleotide may be modified.
More particularly, the invention relates to the assembly of oligonucleotides having modified internucleotide linkages.
This holds true whether the internucleotide linkages of the " altimer " are phosphodiester or phosphorothioate linkages.
The oligonucleotides may have modified sugar components, modified nucleobase components or modified internucleotide linkages.
For example, one or more internucleotide linkages in the antisense oligonucleotide may have a cationic modification.
Therefore, when designing nucleic acid molecules, the amount of these internucleotide linkages should be minimized.
Oligonucleotides comprising different internucleotide linkages are also contemplated, e.g., mixed phosphorothioate phosphodiesters.
In yet another embodiment, the oligonucleotide primer may comprise multiple noncontiguous 3 ' modified internucleotide linkages.
Suitable sulphur ( S ) containing internucleotide linkages as provided herein may be preferred.
Preferred oligonucleotides have the following sequences, The sequences preferably contain all phosphorothioate modified internucleotide linkages.
In particular, phosphodiester or phosphodiester-like internucleotide linkages involve " internal dinucleotides ".
Preferred stabilized internucleotide linkages include, without limitation, phosphorothioate, phosphorodithioate, methylphosphonate, and methylphosphorothioate.
Dimer blocks are dimeric nucleotides having modified internucleotide linkages and blocking groups at the 5 ' - hydroxyl.
Such modified oligonucleotides preferably also have from 1 to about all modified ( non-phosphodiester ) internucleotide linkages.
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All of the internucleotide linkages are phosphorothioate linkages
The bases react to form an internucleotide phosphite bond
The internucleotide linkages of each compound are phosphorothioate throughout
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