Examples of 'modified oligonucleotide' in a sentence
Meaning of "modified oligonucleotide"
modified oligonucleotide - A type of genetic material that has been altered or changed, typically in a laboratory setting. Modified oligonucleotides are often used in research, diagnostics, and therapeutics
How to use "modified oligonucleotide" in a sentence
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modified oligonucleotide
Modified oligonucleotide is construed in the following manner.
This results in an internally amino modified oligonucleotide.
A modified oligonucleotide may also be a capped species.
The reagents comprise a modified oligonucleotide and a polymerase.
A modified oligonucleotide may also be capped.
The probe or the primer is then a modified oligonucleotide.
At least one modified oligonucleotide according to the invention.
Various labels can be introduced into a modified oligonucleotide.
This modified oligonucleotide bears a net negative charge.
Also disclosed are kits containing a modified oligonucleotide primer.
Modified oligonucleotide primers as disclosed herein have two states.
The conjugate group is covalently attached to the modified oligonucleotide.
Use of a modified oligonucleotide.
In other embodiments the modified backbone is a peptide modified oligonucleotide backbone.
A modified oligonucleotide can comprise one or more substituted sugar moieties.
See also
This modification also increases the nuclease resistance of the modified oligonucleotide.
Synthesis of the modified oligonucleotide was performed using phosphoramidite chemical synthesis.
An unlabelled helper probe may be used in combination with the modified oligonucleotide.
Such modified oligonucleotide decoys may preferentially traverse the cell membrane.
The use of any preceding claim wherein the siRNA comprises a modified oligonucleotide.
The modified oligonucleotide may comprise at least one modified internucleoside linkage.
An AON of the invention is preferably a modified oligonucleotide.
The modified oligonucleotide primer has at least one modified internucleotide linkage.
This material was inserted into the DNA synthesizer and an modified oligonucleotide produced.
The improvement comprises using a modified oligonucleotide in place of the first oligonucleotide primer.
In certain embodiments, the antisense compound is a modified oligonucleotide.
Controlled degradation of the modified oligonucleotide provides for production of oligonucleotide primer that is extendable.
In certain embodiments, the nucleic acid is a modified oligonucleotide.
In certain embodiments, the modified oligonucleotide is a single-stranded oligonucleotide.
In certain embodiments, the compound targeting ApoCIII is a modified oligonucleotide.
In certain embodiments, a modified oligonucleotide comprises one or more modified nucleosides.
Various non-standard bases can be introduced into a modified oligonucleotide.
In certain embodiments, a modified oligonucleotide comprises one or more internucleoside modifications.
In certain embodiments, the antisense compound is single-stranded modified oligonucleotide.
In certain embodiments, a modified oligonucleotide comprises one or more modified nucleobases.
The use of claim 6 wherein the compound comprises a modified oligonucleotide.
In certain embodiments, a modified oligonucleotide comprises at least one phosphorothioate internucleoside linkage.
In certain instances, the antisense compound comprises a shortened or truncated modified oligonucleotide.
The ApoCIII inhibitor, compound or modified oligonucleotide is in a salt form.
In certain embodiments, the antisense compound comprises a lengthened or long modified oligonucleotide.
The preparation process for said modified oligonucleotide comprises at least,.
In certain embodiments, the compound provided herein consists of a single-stranded modified oligonucleotide.
In certain embodiments, one or more modified oligonucleotide provided herein is formulated as a prodrug.
In certain embodiments, the compound of the invention consists of a single-stranded modified oligonucleotide.
Such oligonucleotide probes are preferably modified oligonucleotide which are resistant to endogenous nucleases, e . g.
The modified oligonucleotide for use of any of the above claims, wherein the administering,.
In certain embodiments, each internucleoside linkage of a modified oligonucleotide is a phosphorothioate internucleoside linkage.
In certain embodiments, the compounds or compositions provided herein comprise a salt of the modified oligonucleotide.
In certain embodiments, the modified oligonucleotide has at least one modified internucleoside linkage.
In certain embodiments, the oligonucleotide targeting ApoCIII is a modified oligonucleotide targeting ApoCIII.
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